Professor Donna Wilcock describes neurofibrillary tangles, which form inside the neuron in Alzheimer's disease and are composed of tau proteins.
Neurofibrillary tangles â€“ Iâ€™m going to say 'tangles' to make this simpler. Now weâ€™re talking about intracellular proteins. So neurofibrillary tangles form inside the neuron and these are composed of abnormally processed tau. Tau is associated with the microtubules, which, if you think about the neuron, you have the cell body and then you have the axon, which can run for many, many centimeters (meters in some cases) and along the axon you have train tracks called microtubules that are involved in transport of something from the cell body to the synapse. Tau is thought to be involved in the movement of proteins, anything really, from the cell body to the axon. Tau in Alzheimerâ€™s disease gets what we call hyper-phosphorylated, which means that you add phosphate groups to the protein. When you do this in an abnormal fashion, the tau moves away from the microtubule and will aggregate. So, itâ€™s the same as the amyloid beta, which is you will get multiple tau proteins coming together and clumping up, but this time they clump up inside the cell. When they clump up inside the cell, we believe that this causes the neuron to become stressed and eventually die.
neurofibrillary, tangle, tau, protein, microtubule, alzheimer, disease, phosphate groups, amyloid, beta, donna, wilcock
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1452. Tau Gene (MAPT)
Neurofibrillary tangles are bundles of tau proteins, which mark the tau gene (MAPT) as a strong candidate for Alzheimer’s disease.
2227. Alzheimer's disease
An overview of Alzheimer's disease-related content on Genes to Cognition Online.
2180. Immunotherapy fights Alzheimer's disease
Professor Donna Wilcock discusses an exciting finding from her research group that uses immunotherapy to prevent neurofibrillary tangles in mice.
1447. Alzheimer's Disease Candidate Genes
Genes that can cause neurofibrillary tangles and amyloid plaques are strongly associated with Alzheimer's disease.
2174. Neuron loss
Professor Donna Wilcock describes how neurofibrillary tangles choke neurons, causing them to die. This is one of three hallmarks of Alzheimer's disease.
2029. Neurofibrillary tangles and Alzheimer's disease
Professor Kenneth Kosik discusses neurofibrillary tangles, which form inside a cell and are made up of a protein called tau. There is a strong relationship with plaques and amyloid deposition.
2030. Tau protein and Alzheimer's disease
Professor Kenneth Kosik discusses the tau protein and its relationship to the neurofibrillary tangles found in Alzheimer's disease.
2336. Neurofibrillary Tangles - Hallmark of Alzheimer's Disease
Doctor Brian Bacskai discusses what a tangle is and how it leads to death of neurons.
2172. Amyloid plaques
Professor Donna Wilcock describes amyloid plaques as clumps of protein in the brain that are one of the three hallmarks of Alzheimer's disease.
2189. Late-onset Alzheimer's disease
Professor Donna Wilcock discusses late-onset Alzheimer's disease, which involves the clearance and/or production of the amyloid beta protein.