Tau Gene (MAPT)
Neurofibrillary tangles are bundles of tau proteins, which mark the tau gene (MAPT) as a strong candidate for Alzheimerâ€™s disease.
Senile plaques and neurofibrillary tangles are the primary indicators of Alzheimer's disease in the brain. Plaques are formed from deposits of amyloid-beta peptide. Neurofibrillary tangles are bundles of tau proteins, which mark the tau gene (microtubule-associated protein tau, MAPT) as a strong candidate for Alzheimerâ€™s disease. Tau proteins are widely expressed in neurons and interact with tubulin to help assemble microtubules, scaffold-like structures that maintain a cellâ€™s shape. Microtubules are one of the components of the cytoskeleton. Mutations of the tau gene are known to cause frontal temporal dementia, which is similar to Alzheimerâ€™s disease (although the pathology is different). More convincingly, Conrad and colleagues (2002) identified a single nucleotide polymorphism in the tau gene (MAPT) that was more common in individuals with late onset Alzheimerâ€™s disease.
alzheimer's, genes, tau gene, neurofibrillary tangles, neurons, protein, tubulin, tangles, frontal temporal dementia,
- ID: 1452
- Source: DNALC.G2C
Doctor Brian Bacskai discusses what a tangle is and how it leads to death of neurons.
Genes that can cause neurofibrillary tangles and amyloid plaques are strongly associated with Alzheimer's disease.
Professor Donna Wilcock describes how neurofibrillary tangles choke neurons, causing them to die. This is one of three hallmarks of Alzheimer's disease.
Professor Kenneth Kosik discusses the tau protein and its relationship to the neurofibrillary tangles found in Alzheimer's disease.
Professor Kenneth Kosik discusses neurofibrillary tangles, which form inside a cell and are made up of a protein called tau. There is a strong relationship with plaques and amyloid deposition.
Professor Donna Wilcock describes neurofibrillary tangles, which form inside the neuron in Alzheimer's disease and are composed of tau proteins.
An overview of Alzheimer's disease-related content on Genes to Cognition Online.
Alzheimer’s disease is a progressive brain disorder that causes a gradual and irreversible loss of higher brain functions, including memory, language skills, and perception of time and space,
Professor Donna Wilcock discusses an exciting finding from her research group that uses immunotherapy to prevent neurofibrillary tangles in mice.
Alzheimer's disease is characterized by abnormal plaques and tangles in the brains of patients.