Neurofibrillary Tangles - Hallmark of Alzheimer's Disease
Doctor Brian Bacskai discusses what a tangle is and how it leads to death of neurons.
Neurofibrillary tangles are the other classic histopathological hallmark of Alzheimerâ€™s disease. [They] are an intracellular lesion based on aberrant phosphorylation of the Tau protein that lead to sort of an accumulation of Tau, known as a tangle, inside the cell, ultimately leading to death of those neurons.
neurofibrillary, tangle, tau, protein, hallmark, alzheimer, brian, bacskai
Professor Kenneth Kosik discusses neurofibrillary tangles, which form inside a cell and are made up of a protein called tau. There is a strong relationship with plaques and amyloid deposition.
Neurofibrillary tangles are bundles of tau proteins, which mark the tau gene (MAPT) as a strong candidate for Alzheimer’s disease.
Professor Donna Wilcock describes how neurofibrillary tangles choke neurons, causing them to die. This is one of three hallmarks of Alzheimer's disease.
Professor Kenneth Kosik discusses the tau protein and its relationship to the neurofibrillary tangles found in Alzheimer's disease.
Professor Donna Wilcock describes neurofibrillary tangles, which form inside the neuron in Alzheimer's disease and are composed of tau proteins.
Doctor Brian Bacskai discusses how his group uses optical image to record plaque formation in Alzheimer's-type mice.
An overview of Alzheimer's disease-related content on Genes to Cognition Online.
Genes that can cause neurofibrillary tangles and amyloid plaques are strongly associated with Alzheimer's disease.
Doctor Brian Bacskai discusses how Amyloid plaques lead to a definitive diagnosis of alzheimer's disease.
Professor Donna Wilcock discusses an exciting finding from her research group that uses immunotherapy to prevent neurofibrillary tangles in mice.