Neurofibrillary tangles and Alzheimer's disease
Professor Kenneth Kosik discusses neurofibrillary tangles, which form inside a cell and are made up of a protein called tau. There is a strong relationship with plaques and amyloid deposition.
The other hallmark of Alzheimerâ€™s disease is the neurofibrillary tangle. That is made up of a different protein, a protein called tau (T-A-U, the Greek letter tau), and in contrast to the plaque, the tangle forms inside the cell. Now, there has been a debate for a long time about the primacy of the tangles or the plaques in the disease, and even more importantly what is the relationship between the two? We now know that fundamental in the disease process of Alzheimerâ€™s disease, the fundamental pathogenesis of Alzheimerâ€™s disease, is the plaque and the amyloid deposition. Then, secondarily, the amyloid triggers this reaction in cells to form tangles.
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Neurofibrillary tangles are bundles of tau proteins, which mark the tau gene (MAPT) as a strong candidate for Alzheimer’s disease.
An overview of Alzheimer's disease-related content on Genes to Cognition Online.
Professor Kenneth Kosik discusses the tau protein and its relationship to the neurofibrillary tangles found in Alzheimer's disease.
Professor Kenneth Kosik describes senile plaques, an extracellular collection of a-beta protein. It is one of the hallmarks of Alzheimer's disease.
Genes that can cause neurofibrillary tangles and amyloid plaques are strongly associated with Alzheimer's disease.
Professor Kenneth Kosik defines Alzheimer's disease as a slowly progressing illness that deteriorates the brain and impairs many major cognitive functions.
Doctor Brian Bacskai discusses what a tangle is and how it leads to death of neurons.
Professor Donna Wilcock describes neurofibrillary tangles, which form inside the neuron in Alzheimer's disease and are composed of tau proteins.
Professor Donna Wilcock discusses an exciting finding from her research group that uses immunotherapy to prevent neurofibrillary tangles in mice.
Professor Donna Wilcock describes how neurofibrillary tangles choke neurons, causing them to die. This is one of three hallmarks of Alzheimer's disease.