Tau protein and Alzheimer's disease
Professor Kenneth Kosik discusses the tau protein and its relationship to the neurofibrillary tangles found in Alzheimer's disease.
Tau is the protein that is formed in the neurofibrillary tangle, but tau is also a normal protein that we all have in our brain. It is mostly present in the axon of a neuron, the part that is projecting a long distance. In the axon, it is attached to the microtubules. You can think of tau as the ties along railroad tracks, with the railroad tracks being the microtubules and the ties being the tau protein. The purpose of this system of tau and microtubules is for moving cargo down these long distances, the long axons. Now, there has been some speculation that tau, because tau is a little complicated in all the different isoforms, the different forms it can have in the brain, that perhaps its regulation may indeed have some role in cognition. But we know very, very little about that at this time.
tau protein, neurofibrillary, tangle, axon, microtubules, isoforms, cognition, kenneth, kosik
Professor Kenneth Kosik discusses neurofibrillary tangles, which form inside a cell and are made up of a protein called tau. There is a strong relationship with plaques and amyloid deposition.
Professor Donna Wilcock describes neurofibrillary tangles, which form inside the neuron in Alzheimer's disease and are composed of tau proteins.
Neurofibrillary tangles are bundles of tau proteins, which mark the tau gene (MAPT) as a strong candidate for Alzheimer’s disease.
An overview of Alzheimer's disease-related content on Genes to Cognition Online.
Professor Kenneth Kosik defines Alzheimer's disease as a slowly progressing illness that deteriorates the brain and impairs many major cognitive functions.
Doctor Brian Bacskai discusses what a tangle is and how it leads to death of neurons.
Genes that can cause neurofibrillary tangles and amyloid plaques are strongly associated with Alzheimer's disease.
Professor Kenneth Kosik describes senile plaques, an extracellular collection of a-beta protein. It is one of the hallmarks of Alzheimer's disease.
Professor Donna Wilcock describes how neurofibrillary tangles choke neurons, causing them to die. This is one of three hallmarks of Alzheimer's disease.
Professor Kenneth Kosik discusses the biochemistry of Alzheimer's disease in relation to acetylcholine and cholinergic deficiency.