Acetylcholine and Alzheimer's disease
Professor Kenneth Kosik discusses the biochemistry of Alzheimer's disease in relation to acetylcholine and cholinergic deficiency.
When looking that the pathology of Alzheimerâ€™s disease we focus, of course, on the plaques and the tangles. However, before we began to actually get at the molecular underpinnings of the plaques and the tangles, there had been another very important discovery which is that certain types of neurons that use a transmitter called acetylcholine seem to be impaired more than other neurons in the brain. We call that a cholinergic deficit. For a long time many of the therapies directed toward Alzheimerâ€™s were intended to replace the missing acetylcholine. We now have gone beyond that to try to get toward what we call disease-modifying drugs, those drugs that are going to really affect the origins of the disease, so the plaques and tangles themselves.
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Professor Donna Wilcock dscusses the cholinergic hypothesis of Alzheimer's disease, which focuses on cholinergic neurons. The hypothesis has not been supported.
Professor Kenneth Kosik defines Alzheimer's disease as a slowly progressing illness that deteriorates the brain and impairs many major cognitive functions.
Professor Kenneth Kosik discusses some of the brain regions specifically associated with Alzheimer's disease, including the hippocampus, amygdala, and entorhinal cortex.
Professor Kenneth Kosik discusses the relationship between mild cognitive impairment (MCI) and Alzheimer’s disease. MCI is a predictor of Alzheimer's disease.
Professor Kenneth Kosik discusses the neuropathology of Alzheimer's disease, which affects the hippocampus, amygdala, and cortical areas. Areas, such as the cerebellum, are unaffected.
Professor Kenneth Kosik describes senile plaques, an extracellular collection of a-beta protein. It is one of the hallmarks of Alzheimer's disease.
Professor Kenneth Kosik describes the relationship between the amyloid precursor protein (APP) and Alzheimer’s disease. APP mutations are linked to early-onset Alzheimer’s disease.
Professor Kenneth Kosik discusses neurofibrillary tangles, which form inside a cell and are made up of a protein called tau. There is a strong relationship with plaques and amyloid deposition.
Professor Kenneth Kosik discusses early-onset Alzheimer's disease, which affects 1% of all people with the disease.
An overview of Alzheimer's disease-related content on Genes to Cognition Online.