Alzheimer’s disease - early onset
Professor Kenneth Kosik discusses early-onset Alzheimer's disease, which affects 1% of all people with the disease.
Alzheimer’s disease is not a monolithic entity. It comes in some different varieties, and perhaps one way to divvy up the clinical realm is looking at the age of onset. There is a group of people who have an early age of onset. Those people often have Alzheimer’s disease running in their families and, as we’ve learned more and more about that group, we’ve come to realize that they do indeed represent a very special category. Many of the people with early-onset Alzheimer’s, who have a family history, will also carry a gene mutation; a mutation that leads to Alzheimer’s disease in 50% of the offspring of the person who already has it. About 1% of all people with Alzheimer’s disease have this form, and for those who carry that particular kind of mutation, the likelihood of getting it approaches 100% - in contrast to some other types of mutations that we know about, where your risk increases but you don’t have this very inevitable possibility of developing the disease.
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Professor Kenneth Kosik describes the relationship between the amyloid precursor protein (APP) and Alzheimer’s disease. APP mutations are linked to early-onset Alzheimer’s disease.
Professor Kenneth Kosik discusses lifestyle factors that will delay onset of Alzheimer’s disease. These include diet, exercise, controlling hypertension, and not smoking.
Professor Kenneth Kosik discusses the relationship between mild cognitive impairment (MCI) and Alzheimer’s disease. MCI is a predictor of Alzheimer's disease.
Professor Donna Wilcock discusses early-onset Alzheimer's disease, which can reach an advanced stage by the age of 50 or 60 years.
Professor Kenneth Kosik defines Alzheimer's disease as a slowly progressing illness that deteriorates the brain and impairs many major cognitive functions.
Alzheimer’s disease is a progressive brain disorder that causes a gradual and irreversible loss of higher brain functions, including memory, language skills, and perception of time and space,
An overview of Alzheimer's disease-related content on Genes to Cognition Online.
Professor Kenneth Kosik explains that Alzheimer's disease is traditionally diagnosed by a physician taking a history and physical. In the near future, neuroimaging will provide an accurate diagnosis.
Professor Kenneth Kosik discusses some of the brain regions specifically associated with Alzheimer's disease, including the hippocampus, amygdala, and entorhinal cortex.
Professor Kenneth Kosik discusses the neuropathology of Alzheimer's disease, which affects the hippocampus, amygdala, and cortical areas. Areas, such as the cerebellum, are unaffected.