Testing for Alzheimerâ€™s disease
Professor Kenneth Kosik explains that Alzheimer's disease is traditionally diagnosed by a physician taking a history and physical. In the near future, neuroimaging will provide an accurate diagnosis.
Testing for Alzheimerâ€™s disease can be a little bit difficult but the approaches are improving very, very rapidly. The best way we have now to actually test remains to do the classical work that physicians have done for a long time â€“ that is to simply get a history and physical. From a history and physical, that is a history of slow and insidious decline in cognition (and when I say â€˜slowâ€™ I mean over years not over weeks), if you begin to get that history then suspicion rises greatly. But to move from the point of suggestive to actually being quite certain that the disease is Alzheimerâ€™s, one needs some laboratory testing, one needs to do a scan, and then we can get upwards of 90% probability that the person has Alzheimerâ€™s disease. One more point is that in the very near future, probably within the next year perhaps, we, as a field, have developed the ability to actually image in living people the senile plaques. Diagnosis will probably move from the 90% level of certainty up to really approaching 100%.
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Professor Kenneth Kosik defines Alzheimer's disease as a slowly progressing illness that deteriorates the brain and impairs many major cognitive functions.
Professor Kenneth Kosik describes senile plaques, an extracellular collection of a-beta protein. It is one of the hallmarks of Alzheimer's disease.
Professor Kenneth Kosik describes the relationship between the amyloid precursor protein (APP) and Alzheimer’s disease. APP mutations are linked to early-onset Alzheimer’s disease.
Professor Kenneth Kosik discusses neurofibrillary tangles, which form inside a cell and are made up of a protein called tau. There is a strong relationship with plaques and amyloid deposition.
Professor Kenneth Kosik discusses the biochemistry of Alzheimer's disease in relation to acetylcholine and cholinergic deficiency.
An overview of Alzheimer's disease-related content on Genes to Cognition Online.
Doctor Brian Bacskai discusses how Amyloid plaques lead to a definitive diagnosis of alzheimer's disease.
Bio-barcode amplification (BCA) is a new technique that can search for biological markers of Alzheimer's disease, which may lead to earlier diagnosis.
Professor Donna Wilcock discusses a new biological technique for diagnosing Alzheimer's disease using PET neuroimaging.
Professor Kenneth Kosik discusses some of the brain regions specifically associated with Alzheimer's disease, including the hippocampus, amygdala, and entorhinal cortex.