Neuropathology of Alzheimer's disease
Professor Kenneth Kosik discusses some of the brain regions specifically associated with Alzheimer's disease, including the hippocampus, amygdala, and entorhinal cortex.
There are regions of the brain that are specifically affected in Alzheimer’s disease and they include the hippocampus, the amygdala the entorhinal cortex, and the pathology showing up in those regions tends to correlate to what we see clinically. So the hippocampus is thought to be a memory part of the brain, and indeed individuals with Alzheimer’s have memory trouble, the amygdala is a part of the brain that is involved in emotion, and emotional dysfunction is a major component in Alzheimer’s. Tangles also affect deeper structures down in the brainstem, which control our sleep/wake cycles, and indeed it is a well-known complaint of Alzheimer’s disease to have a loss of their normal sleep cycles.
alzheimers', alzheimer, neuropathology, hippocampus, amygdala, entorhinal cortex, memory, kenneth, kosik
Professor Kenneth Kosik discusses the neuropathology of Alzheimer's disease, which affects the hippocampus, amygdala, and cortical areas. Areas, such as the cerebellum, are unaffected.
An overview of Alzheimer's disease-related content on Genes to Cognition Online.
Professor Donna Wilcock describes the neuropathology of Alzheimer's disease as it progresses from the hippocampus to other brain areas.
Professor Kenneth Kosik defines Alzheimer's disease as a slowly progressing illness that deteriorates the brain and impairs many major cognitive functions.
The entorhinal cortex plays a major role in memory formation. Two major connections from the entorhinal area input to the hippocampus and are important to pre–processing memory information.
Professor Kenneth Kosik discusses the relationship between mild cognitive impairment (MCI) and Alzheimer’s disease. MCI is a predictor of Alzheimer's disease.
Professor Dennis Selkoe discusses the age at which plaque-forming a-beta can begin to build up. Children with Down syndrome may have these plaques, otherwise childhood instances are rare.
Professor Kenneth Kosik describes senile plaques, an extracellular collection of a-beta protein. It is one of the hallmarks of Alzheimer's disease.
Professor Kenneth Kosik discusses the biochemistry of Alzheimer's disease in relation to acetylcholine and cholinergic deficiency.
Professor Kenneth Kosik describes the relationship between the amyloid precursor protein (APP) and Alzheimer’s disease. APP mutations are linked to early-onset Alzheimer’s disease.