Alzheimer's disease - selective neuropathology
Professor Kenneth Kosik discusses the neuropathology of Alzheimer's disease, which affects the hippocampus, amygdala, and cortical areas. Areas, such as the cerebellum, are unaffected.
One of the most interesting questions in the area of all neurodegenerative illnesses, including Alzheimer’s disease, is why in these illnesses are certain types of neurons affected and others are not affected? In Alzheimer’s disease, we know that areas such as the hippocampus, the amygdala, and certain areas of the cortex are severely affected but other neurons that have very similar types of structures - axons, dendrites, such as those in the cerebellum are not affected at all. We see this theme again and again in neurodegeneration. For instance, the substantia nigra is affected in Parkinson’s disease, the anterior horn cells of the spinal cord are affected in ALS or Lou Gehrig’s disease. So neurodegenerative diseases, including Alzheimer’s, have very interesting and specific topographies that we still have a lot to learn about.
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Professor Kenneth Kosik discusses some of the brain regions specifically associated with Alzheimer's disease, including the hippocampus, amygdala, and entorhinal cortex.
Professor Kenneth Kosik defines Alzheimer's disease as a slowly progressing illness that deteriorates the brain and impairs many major cognitive functions.
An overview of Alzheimer's disease-related content on Genes to Cognition Online.
Professor Kenneth Kosik discusses the relationship between mild cognitive impairment (MCI) and Alzheimer’s disease. MCI is a predictor of Alzheimer's disease.
Professor Kenneth Kosik describes senile plaques, an extracellular collection of a-beta protein. It is one of the hallmarks of Alzheimer's disease.
Professor Kenneth Kosik discusses the biochemistry of Alzheimer's disease in relation to acetylcholine and cholinergic deficiency.
Professor Kenneth Kosik describes the relationship between the amyloid precursor protein (APP) and Alzheimer’s disease. APP mutations are linked to early-onset Alzheimer’s disease.
Professor Kenneth Kosik discusses neurofibrillary tangles, which form inside a cell and are made up of a protein called tau. There is a strong relationship with plaques and amyloid deposition.
Professor Kenneth Kosik discusses early-onset Alzheimer's disease, which affects 1% of all people with the disease.
Professor Donna Wilcock describes the neuropathology of Alzheimer's disease as it progresses from the hippocampus to other brain areas.