Senile plaques and Alzheimer's disease
Professor Kenneth Kosik describes senile plaques, an extracellular collection of a-beta protein. It is one of the hallmarks of Alzheimer's disease.
As many people now are aware, the classical stigmata of Alzheimerâ€™s disease, the classical hallmarks, are plaques and tangles. The senile plaque is an extracellular collection of protein. Itâ€™s a protein that is referred to as the a-beta. Itâ€™s a fragment of a normal protein we all have called the amyloid precursor protein. It gets chopped into a smaller piece called a-beta that then collects, assembles outside of cells, and forms this aggregate mass that forms a ball between the neurons, between the interstices of the brain, and pushes aside all of the fine ramifications and connections of brain cells to form what we call a plaque.
senile, plaques, amyloid precursor protein, abeta, interstice, kenneth, kosik
- ID: 2028
- Source: DNALC.G2C
- Download: Theora Video MPEG 4 Video Windows Media Video
2033. Amyloid precursor protein and Alzheimer's disease
Professor Kenneth Kosik describes the relationship between the amyloid precursor protein (APP) and Alzheimer’s disease. APP mutations are linked to early-onset Alzheimer’s disease.
2029. Neurofibrillary tangles and Alzheimer's disease
Professor Kenneth Kosik discusses neurofibrillary tangles, which form inside a cell and are made up of a protein called tau. There is a strong relationship with plaques and amyloid deposition.
2025. What is Alzheimer's disease?
Professor Kenneth Kosik defines Alzheimer's disease as a slowly progressing illness that deteriorates the brain and impairs many major cognitive functions.
2172. Amyloid plaques
Professor Donna Wilcock describes amyloid plaques as clumps of protein in the brain that are one of the three hallmarks of Alzheimer's disease.
2227. Alzheimer's disease
An overview of Alzheimer's disease-related content on Genes to Cognition Online.
1448. APP Gene
Amyloid precursor protein (APP) is expressed in the synapses of neurons and is thought to be responsible for forming and repairing synapses.
2335. Amyloid Plaques - Hall mark of Alzheimer's Disease
Doctor Brian Bacskai discusses how Amyloid plaques lead to a definitive diagnosis of alzheimer's disease.
2135. APP - amyloid clearance and production
Professor Dennis Selkoe compares the amyloid precursor (or parent) protein to a Bic pen. The clasp part seems to be the bad guy, and is part of a network involving presenilin and ApoE4.
2134. Amyloid hypothesis - beta oligomers and plaques
Professor Dennis Selkoe explains that amyloid beta oligomers - small assemblies of amyloid beta protein associated with Alzheimer's disease - do not cause plaques but prevent them.
2137. Amyloid plaques - rarely found in childhood
Professor Dennis Selkoe discusses the age at which plaque-forming a-beta can begin to build up. Children with Down syndrome may have these plaques, otherwise childhood instances are rare.