Professor Donna Wilcock describes amyloid plaques as clumps of protein in the brain that are one of the three hallmarks of Alzheimer's disease.
Amyloid plaques are, I would say, clumps of protein that are in the brain in the extracellular space, meaning that they are outside of any cells. They are just situated between neurons within the brain, and these are composed of multiple amyloid beta peptides. So, the a-beta peptide is a very short, 40 or 42 amino acid long protein. When you get multiple amyloid beta peptides coming together, they form an insoluble piece of protein called an amyloid plaque. So this is one of the three pathological markers that we know cause Alzheimerâ€™s disease.
amyloid, plaque, alzheimer, disease, beta, abeta, a-beta, protein, donna, wilcock
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2189. Late-onset Alzheimer's disease
Professor Donna Wilcock discusses late-onset Alzheimer's disease, which involves the clearance and/or production of the amyloid beta protein.
2180. Immunotherapy fights Alzheimer's disease
Professor Donna Wilcock discusses an exciting finding from her research group that uses immunotherapy to prevent neurofibrillary tangles in mice.
2028. Senile plaques and Alzheimer's disease
Professor Kenneth Kosik describes senile plaques, an extracellular collection of a-beta protein. It is one of the hallmarks of Alzheimer's disease.
2227. Alzheimer's disease
An overview of Alzheimer's disease-related content on Genes to Cognition Online.
2182. Alzheimer's disease therapy - clinical trials
Professor Donna Wilcock discusses the process of going from a mouse model to human trials for testing the amyloid beta immunization for Alzheimer's disease.
2137. Amyloid plaques - rarely found in childhood
Professor Dennis Selkoe discusses the age at which plaque-forming a-beta can begin to build up. Children with Down syndrome may have these plaques, otherwise childhood instances are rare.
2134. Amyloid hypothesis - beta oligomers and plaques
Professor Dennis Selkoe explains that amyloid beta oligomers - small assemblies of amyloid beta protein associated with Alzheimer's disease - do not cause plaques but prevent them.
2136. Amyloid beta causing forgetfulness
Professor Dennis Selkoe discusses an experiment by his group, which found that a-beta oligomers temporarily injected into rats' brains caused temporary forgetfulness.
2335. Amyloid Plaques - Hall mark of Alzheimer's Disease
Doctor Brian Bacskai discusses how Amyloid plaques lead to a definitive diagnosis of alzheimer's disease.
2188. Early-onset Alzheimer's disease, 30-65
Professor Donna Wilcock discusses early-onset Alzheimer's disease, which can reach an advanced stage by the age of 50 or 60 years.