Late-onset Alzheimer's disease
Professor Donna Wilcock discusses late-onset Alzheimer's disease, which involves the clearance and/or production of the amyloid beta protein.
Late-onset Alzheimerâ€™s disease is really of no known cause yet. We really donâ€™t know that causes this. The field is leaning toward it being less of an amyloid production problem and more of an amyloid clearance problem. We think there is a fine balance between production and clearance of amyloid beta [a-beta] peptides. Letâ€™s say you shift it one way, where you are increasing production but clearance stays the same, we think this is what happens in the familial Alzheimerâ€™s disease where we see these mutations. But if you shift it the other way, and now production stays the same, but youâ€™re less able to clear that a-beta out of the brain, now youâ€™re going to start accumulating the amyloid beta. We think this is what happens in late-onset Alzheimerâ€™s disease and we donâ€™t really know why.
alzheimer, late, onset, gene, apoe, apoe4, apoe3, apoe2, donna, wilcock
- ID: 2189
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2190. Late-onset genes for Alzheimer's disease
Professor Donna Wilcock discusses the late-onset gene for Alzheimer's disease, ApoE4, which increases the risk of developing the disease.
1451. Apolipoprotein (APOE) Gene
Individuals with two copies of APOE4, have a dramatically increased risk of developing Alzheimer’s disease.
1447. Alzheimer's Disease Candidate Genes
Genes that can cause neurofibrillary tangles and amyloid plaques are strongly associated with Alzheimer's disease.
2138. ApoE4, a-beta, and Alzheimer's disease susceptibility
Professor Dennis Selkoe discusses the degree to which the ApoE4 gene is associated with early onset Alzheimer's disease.
2188. Early-onset Alzheimer's disease, 30-65
Professor Donna Wilcock discusses early-onset Alzheimer's disease, which can reach an advanced stage by the age of 50 or 60 years.
2033. Amyloid precursor protein and Alzheimer's disease
Professor Kenneth Kosik describes the relationship between the amyloid precursor protein (APP) and Alzheimer’s disease. APP mutations are linked to early-onset Alzheimer’s disease.
2227. Alzheimer's disease
An overview of Alzheimer's disease-related content on Genes to Cognition Online.
2183. Alzheimer's disease statistics - prevalence and age
Professor Donna Wilcock discusses Alzheimer's disease in the light of increasing prevalence as the population ages.
2005. Alzheimer's - closing in on early diagnosis
Doctor Thomas Insel discusses recent findings of structural changes in the brains of teenagers may be warning signs for the potential onset of Alzheimer's disease.
794. Background to Alzheimer's Disease
Alzheimer’s disease is a progressive brain disorder that causes a gradual and irreversible loss of higher brain functions, including memory, language skills, and perception of time and space,