Late-onset Alzheimer's disease

Professor Donna Wilcock discusses late-onset Alzheimer's disease, which involves the clearance and/or production of the amyloid beta protein.

Late-onset Alzheimer’s disease is really of no known cause yet. We really don’t know that causes this. The field is leaning toward it being less of an amyloid production problem and more of an amyloid clearance problem. We think there is a fine balance between production and clearance of amyloid beta [a-beta] peptides. Let’s say you shift it one way, where you are increasing production but clearance stays the same, we think this is what happens in the familial Alzheimer’s disease where we see these mutations. But if you shift it the other way, and now production stays the same, but you’re less able to clear that a-beta out of the brain, now you’re going to start accumulating the amyloid beta. We think this is what happens in late-onset Alzheimer’s disease and we don’t really know why.

alzheimer, late, onset, gene, apoe, apoe4, apoe3, apoe2, donna, wilcock

Related Content

2190. Late-onset genes for Alzheimer's disease

Professor Donna Wilcock discusses the late-onset gene for Alzheimer's disease, ApoE4, which increases the risk of developing the disease.

  • ID: 2189
  • Type:
  • Source: G2C

1451. Apolipoprotein (APOE) Gene

Individuals with two copies of APOE4, have a dramatically increased risk of developing Alzheimer’s disease.

  • ID: 2189
  • Type:
  • Source: G2C

1447. Alzheimer's Disease Candidate Genes

Genes that can cause neurofibrillary tangles and amyloid plaques are strongly associated with Alzheimer's disease.

  • ID: 2189
  • Type:
  • Source: G2C

2138. ApoE4, a-beta, and Alzheimer's disease susceptibility

Professor Dennis Selkoe discusses the degree to which the ApoE4 gene is associated with early onset Alzheimer's disease.

  • ID: 2189
  • Type:
  • Source: G2C

2188. Early-onset Alzheimer's disease, 30-65

Professor Donna Wilcock discusses early-onset Alzheimer's disease, which can reach an advanced stage by the age of 50 or 60 years.

  • ID: 2189
  • Type:
  • Source: G2C

2033. Amyloid precursor protein and Alzheimer's disease

Professor Kenneth Kosik describes the relationship between the amyloid precursor protein (APP) and Alzheimer’s disease. APP mutations are linked to early-onset Alzheimer’s disease.

  • ID: 2189
  • Type:
  • Source: G2C

2227. Alzheimer's disease

An overview of Alzheimer's disease-related content on Genes to Cognition Online.

  • ID: 2189
  • Type:
  • Source: G2C

2183. Alzheimer's disease statistics - prevalence and age

Professor Donna Wilcock discusses Alzheimer's disease in the light of increasing prevalence as the population ages.

  • ID: 2189
  • Type:
  • Source: G2C

2005. Alzheimer's - closing in on early diagnosis

Doctor Thomas Insel discusses recent findings of structural changes in the brains of teenagers may be warning signs for the potential onset of Alzheimer's disease.

  • ID: 2189
  • Type:
  • Source: G2C

794. Background to Alzheimer's Disease

Alzheimer’s disease is a progressive brain disorder that causes a gradual and irreversible loss of higher brain functions, including memory, language skills, and perception of time and space,

  • ID: 2189
  • Type:
  • Source: G2C