Apolipoprotein (APOE) Gene
Individuals with two copies of APOE4, have a dramatically increased risk of developing Alzheimerâ€™s disease.
Apolipoprotein (APOE) is a plasma glycoprotein that contains 299 amino acids. APOE transports vitamins, lipoproteins and cholesterol into the lymph system and blood. It is mainly expressed in the liver, but is found in other tissues, including the brain. There are three major isoforms (versions) of APOE â€“ APOE2, APOE3, and APOE4. The APOE4 isoform is particularly associated with Alzheimerâ€™s disease. In individuals with two copies of APOE4, the risk of developing Alzheimerâ€™s disease increases from 20% to 90% and the average age of onset decreases from 84 to 68 years. APOE4 binds to or retains amyloid-beta, which is the primary component of plaques in Alzheimerâ€™s disease.
alzheimer's, genes, apolipoprotein, apoe, apoe4, isoform, lipoproteins, glycoprotein, plaques, amyloid, beta
- ID: 1451
- Source: DNALC.G2C
Genes that can cause neurofibrillary tangles and amyloid plaques are strongly associated with Alzheimer's disease.
Professor Donna Wilcock discusses late-onset Alzheimer's disease, which involves the clearance and/or production of the amyloid beta protein.
Professor Dennis Selkoe discusses the degree to which the ApoE4 gene is associated with early onset Alzheimer's disease.
Professor Donna Wilcock discusses the late-onset gene for Alzheimer's disease, ApoE4, which increases the risk of developing the disease.
Professor Kenneth Kosik describes the relationship between the amyloid precursor protein (APP) and Alzheimer’s disease. APP mutations are linked to early-onset Alzheimer’s disease.
Professor Dennis Selkoe compares the amyloid precursor (or parent) protein to a Bic pen. The clasp part seems to be the bad guy, and is part of a network involving presenilin and ApoE4.
Alzheimer’s disease is a progressive brain disorder that causes a gradual and irreversible loss of higher brain functions, including memory, language skills, and perception of time and space,
Amyloid precursor protein (APP) is expressed in the synapses of neurons and is thought to be responsible for forming and repairing synapses.
Professor Donna Wilcock describes amyloid plaques as clumps of protein in the brain that are one of the three hallmarks of Alzheimer's disease.
Doctor Brian Bacskai discusses how Amyloid plaques lead to a definitive diagnosis of alzheimer's disease.