Mild Cognitive Impairment
Professor Kenneth Kosik discusses the relationship between mild cognitive impairment (MCI) and Alzheimerâ€™s disease. MCI is a predictor of Alzheimer's disease.
Clinicians studying Alzheimerâ€™s disease have begun to get very interested in the earliest stages of Alzheimerâ€™s disease. So when you study people that are often getting up in years, and they are tested on formal neuropsychological testing, they donâ€™t always perform perfectly. They donâ€™t perform as well as we know they would have if we had tested them 10 or 20 years earlier. Now they are still performing well in terms of perhaps their jobs, their hobbies, their activities of daily living, all of their lifestyle activities are perfectly okay. But on formal testing there are some deficits, mild deficits, and we call that minimal [or mild] cognitive impairment. Itâ€™s an entity that increases oneâ€™s risk for Alzheimerâ€™s disease and is really very, very common.
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Professor Kenneth Kosik defines Alzheimer's disease as a slowly progressing illness that deteriorates the brain and impairs many major cognitive functions.
Professor Kenneth Kosik discusses the biochemistry of Alzheimer's disease in relation to acetylcholine and cholinergic deficiency.
Professor Kenneth Kosik discusses lifestyle factors that will delay onset of Alzheimer’s disease. These include diet, exercise, controlling hypertension, and not smoking.
Older individuals with mild cognitive impairment that includes memory problems are much more likely to develop Alzheimer’s disease than are their healthy peers.
Professor Kenneth Kosik discusses some of the brain regions specifically associated with Alzheimer's disease, including the hippocampus, amygdala, and entorhinal cortex.
Professor Dennis Selkoe discusses mild cognitive impaitment, a precursor to Alzheimer's disease. Early identification may be critical to treatment.
Professor Kenneth Kosik explains that Alzheimer's disease is traditionally diagnosed by a physician taking a history and physical. In the near future, neuroimaging will provide an accurate diagnosis.
Professor Kenneth Kosik discusses the tau protein and its relationship to the neurofibrillary tangles found in Alzheimer's disease.
Professor Kenneth Kosik discusses the neuropathology of Alzheimer's disease, which affects the hippocampus, amygdala, and cortical areas. Areas, such as the cerebellum, are unaffected.
Professor Kenneth Kosik describes senile plaques, an extracellular collection of a-beta protein. It is one of the hallmarks of Alzheimer's disease.