Professor Donna Wilcock describes how neurofibrillary tangles choke neurons, causing them to die. This is one of three hallmarks of Alzheimer's disease.
This neuron loss will carry on from the tau pathology. So, you get neurofibrillary tangles inside the neuron, and eventually the neuron â€“ we sometimes think of it as choking up. The neuron will choke on the neurofibrillary tangle and die through several processes, which could be apoptosis, or necrosis. The bottom line is the neuron will fail, will die, and what gets left behind is the tangle. Some pathologists will refer to the tangle as a tombstone, because it reflects where there was once a neuron. Ultimately, we think this neuron loss is what leads to the memory loss, because obviously if you are losing the neurons that hold the memories, then the neuron dying will cause those memories to fall out. So, that is the third hallmark.
alzheimer, disease, neuron, loss, cell, death, neurofibrillary, tangle, tau, hallmark, memory, donna, wilcock
Doctor Brian Bacskai discusses what a tangle is and how it leads to death of neurons.
An overview of Alzheimer's disease-related content on Genes to Cognition Online.
Professor Donna Wilcock describes neurofibrillary tangles, which form inside the neuron in Alzheimer's disease and are composed of tau proteins.
Professor Donna Wilcock explains that Aricept can only provide short-term benefit in treating Alzheimer's disease.
Professor Donna Wilcock discusses an exciting finding from her research group that uses immunotherapy to prevent neurofibrillary tangles in mice.
Neurofibrillary tangles are bundles of tau proteins, which mark the tau gene (MAPT) as a strong candidate for Alzheimer’s disease.
Professor Kenneth Kosik discusses neurofibrillary tangles, which form inside a cell and are made up of a protein called tau. There is a strong relationship with plaques and amyloid deposition.
Genes that can cause neurofibrillary tangles and amyloid plaques are strongly associated with Alzheimer's disease.
Professor Donna Wilcock discusses a new biological technique for diagnosing Alzheimer's disease using PET neuroimaging.
Professor Donna Wilcock dscusses the cholinergic hypothesis of Alzheimer's disease, which focuses on cholinergic neurons. The hypothesis has not been supported.