Optical Imaging of Plaque Formation
Doctor Brian Bacskai discusses how his group uses optical image to record plaque formation in Alzheimer's-type mice.
Our techniques rely on imaging directly; so watching what astrocytes do and what the senile plaques or neurofibrillary tangles are doing in the brain of living animals. This exploits the use of transgenic mice that develop some of these histopathological features in the brain. They are only models of Alzheimerâ€™s disease but they can tell us how these particular pathways affect neuronal and astroglial structure and function. The technique is based on optical imaging using multi-photon microscopy, which is really just a fancy way of using a microscope to see inside an intact, living mouse brain. There we can watch astrocytic cell structure and function over time in response to and in association with senile plaques for instance.
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Doctor Brian Bacskai discusses what a tangle is and how it leads to death of neurons.
Doctor Brian Bacskai explaine that senile plaques lead to an increase in resting calcium in astrocytes in the entire brain.
Doctor Brian Bacskai discusses how Amyloid plaques lead to a definitive diagnosis of alzheimer's disease.
Genes that can cause neurofibrillary tangles and amyloid plaques are strongly associated with Alzheimer's disease.
Professor Kenneth Kosik discusses neurofibrillary tangles, which form inside a cell and are made up of a protein called tau. There is a strong relationship with plaques and amyloid deposition.
Neurofibrillary tangles are bundles of tau proteins, which mark the tau gene (MAPT) as a strong candidate for Alzheimer’s disease.
Doctor Brian Bacskai discusses the potential of manipulating calcium levels in the brain as a potential therapy for ALzheimer's disease.
An overview of Alzheimer's disease-related content on Genes to Cognition Online.
Professor Kenneth Kosik defines Alzheimer's disease as a slowly progressing illness that deteriorates the brain and impairs many major cognitive functions.
Professor Donna Wilcock explains that Aricept can only provide short-term benefit in treating Alzheimer's disease.