Promises of gene therapy, Mario Capecchi
Interviewee: Mario Capecchi. Mario Capecchi talks about the possible use of embryonic stem cells and gene targeting techniques to develop new therapies for for diabetes and Parkinson's. (DNAi Location: Applications > Genes and Medicine > Gene targeting > Possibilities > Possibilities for new therapies)
And the question is, what should you be able to do then, because they show enormous promise in terms of therapeutic, for example somebody that doesn't have the islet cells which are capable of making insulin, they have diabetes, and the question is can you use these cells then to reimplant into the pancreas and thereby regenerate essentially a functional pancreas. Alternatively, there are diseases of the brain, Parkinson disease where particular cells are dying, and these cells may be able to be implanted into the brain and they will then participate in making brain tissues, and thereby then getting around the problem of Parkinson.
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Mario Capecchi talks about manipulating embryonic stem (ES) cells to make specific mutations in mouse embryos.
Mario Capecchi discusses the idea that someday therapies may be created to correct defective genes in egg and sperm cells.
Mario Capecchi talks about the possibility of introducing an artificial chromosome into cells to slow the aging process.
Mario Capecchi talks about the possibility of correcting genetic defects.
Mario Capecchi discusses homologous recombination, the technique he developed to introduce a desired mutation into the DNA of living cells.
Mario Capecchi explains the technique he uses to control genes in mice.
Mario Capecchi continues his explanation of the technique he uses to control genes in mice.
Research continues to show that stem cells could be harnessed for therapeutic purposes.
Mario Capeccchi talks about approaches to making new therapies.
David Botstein (sitting with Pat Brown) talks about how innovations in genomics might lead to personalized medicine.