Approaches to making new therapies, Mario Capecchi
Interviewee: Mario Capeccchi. Mario Capeccchi talks about approaches to making new therapies.
I mean you can either be very straightforward and then for example re-create a particular disease in a mouse, for example we can make a mouse have cystic fibrosis and then study that disease in great detail, much greater detail than you can in humans, in a mouse, and then eventually use the mouse also to develop new therapies. That's a very direct approach. The more indirect approach is to use this technique to learn about the biology of the mouse and thereby then in the future I think will actually be more powerful, because if we understand for example how the brain works then not only will we be able to go after a particular disease, for example schizophrenia, neuro-psychiatric diseases. So once you have an understanding of the process and in great detail, I think you have a much more direct approach to but all actually developing therapies for a variety of diseases as opposed to being a very specific directed way for a particular disease.
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Mario Capecchi talks about the possibility of correcting genetic defects.
Mario Capecchi discusses the idea that someday therapies may be created to correct defective genes in egg and sperm cells.
Mario Capecchi talks about the possible use of embryonic stem cells and gene targeting techniques to develop new therapies for for diabetes and Parkinson's.
Mario Capecchi talks about the advantages of working with mice to study genetic disorders.
Mario Capecchi developed a technique to target and mutate genes in mice using homologous recombination.
Mario Capecchi talks about the possibility of introducing an artificial chromosome into cells to slow the aging process.
Mario Capecchi explains the technique he uses to control genes in mice.
Mario Capecchi works on gene targeting at the University of Utah.
Mario Capecchi at work in his laboratory.
Mario Capecchi describes proteomics; the large-scale study of protein structure and function. Brian Sauer explains gene knock outs.