Gene therapy (germ line), Mario Capecchi
Interviewee: Mario Capecchi. Mario Capecchi discusses the idea that someday therapies may be created to correct defective genes in egg and sperm cells. (DNAi Location: Applications > Genes and Medicine > Gene targeting > Possibilities Cell therapy (germline))
The other is what's called germ line gene therapy in which you would actually alter the gene, not in our own tissues but in the tissues of the eggs and sperm, which would then affect future generations. And there I think we aren't ready to think about that yet, because I think we don't know enough about the genes. I mean if you change genes in your liver it's more or less normal chemistry, you're changing things in the patient. If you change the germ line you're affecting future generation and therefore you would have to know everything about that gene in terms, before you're actually participating in those activities, and I think there we need a lot more wisdom than we presently have.
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Mario Capecchi talks about the possibility of correcting genetic defects.
Mario Capecchi talks about the possible use of embryonic stem cells and gene targeting techniques to develop new therapies for for diabetes and Parkinson's.
Mario Capecchi talks about the possibility of introducing an artificial chromosome into cells to slow the aging process.
Mario Capecchi explains the technique he uses to control genes in mice.
Mario Capeccchi talks about approaches to making new therapies.
Mario Capecchi talks about manipulating embryonic stem (ES) cells to make specific mutations in mouse embryos.
Mario Capecchi continues his explanation of the technique he uses to control genes in mice.
Mario Capecchi discusses homologous recombination, the technique he developed to introduce a desired mutation into the DNA of living cells.
Mario Capecchi developed a technique to target and mutate genes in mice using homologous recombination.
Mario Capecchi discusses the similarities between mouse and human limb formation, and how his work might lead to limb regeneration in the future.