An artificial chromosome?, Mario Capecchi
Interviewee: Mario Capecchi. Mario Capecchi talks about the possibility of introducing an artificial chromosome into cells to slow the aging process. (DNAi Location: Applications > Genes and Medicine > Gene targeting > Possibilities > An artificial chromosome?)
So the thought is, if you can make an artificial chromosome in which many genes have been changed, and then you could actually change many components at the same time, and an example was many of the things that limit our age, how long we live is because we accumulate now many, many mutations in different cells and pretty soon, and we make cell products that are deleterious to the cell, and pretty soon the system simply runs down. And the question is, could we introduce now either corrected genes for those that are being wiped out, and in particular in the engines of the cell, that is the mitochondrial gene which is a fairly limited number of genes, could you replace the ones that are being, dying out in the mitochondria with new copies and thereby make now good mitochondria, therefore our cells are healthy with respect to energy.
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Mario Capecchi talks about the possible use of embryonic stem cells and gene targeting techniques to develop new therapies for for diabetes and Parkinson's.
Mario Capecchi talks about manipulating embryonic stem (ES) cells to make specific mutations in mouse embryos.
Mario Capecchi discusses the idea that someday therapies may be created to correct defective genes in egg and sperm cells.
Mario Capecchi continues his explanation of the technique he uses to control genes in mice.
Mario Capecchi talks about the possibility of correcting genetic defects.
Mario Capecchi explains the technique he uses to control genes in mice.
Mario Capecchi discusses homologous recombination, the technique he developed to introduce a desired mutation into the DNA of living cells.
Molecular geneticist Douglas Wallace talks about the way mitochondrial DNA is inherited.
Mario Capecchi at work in his laboratory.
Mario Capecchi discusses the similarities between mouse and human limb formation, and how his work might lead to limb regeneration in the future.