Promises of genomics, David Botstein
Interviewee: David Botstein. David Botstein (sitting with Pat Brown) talks about how innovations in genomics might lead to personalized medicine. (DNAi Location: Applications > Genes and medicine > Genetic profiling > David Botstein > Promises of genomics)
One of the promises of genomics has been and continues to be that you can personalize medicine by understanding more exactly the particular individual's disease and situation, and that you would use different drugs if you really understood in detail what was going on with each individual. And nowhere is that more true in my opinion than in cancer, each cancer is potentially different and if they may have features in common, and if they have a feature in common that is a target for therapy that's fine, but you cannot assume that they will without actually being able to measure for it, and that's what we expect will happen over the next twenty or so years.
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David Botstein discusses how identifying the molecular mechanisms of cancer will lead to the development of improved therapies.
David Botstein talks about the goal of using microarray analysis to improve cancer diagnosis.
Pat Brown talks about using microarrays to discover the differences between cancer cells and healthy cells.
David Botstein talks about how tumor typing using genome-wide analysis will help doctors determine the most appropriate treatments for their patients.
Pat Brown talks about developing microarray technology for genome-wide analysis.
Pat Brown talks about how the 30,000 spots on the microarray represent genes.
Pat Brown draws an analogy between the genome and a script that tells a cell how to behave.
Pat Brown discusses the early technology behind the microarray.
Stephen Fodor talks about how an individual's gene expression profile can help determine what therapies might work best.
Brian Druker talks about the drug he developed as a turning point in the war on cancer.