Better cancer therapies by identifying oncogenes, David Botstein
Interviewee: David Botstein. David Botstein discusses how identifying the molecular mechanisms of cancer will lead to the development of improved therapies. (DNAi Location: Applications > Genes and medicine > Genetic profiling > David Botstein Better therapies)
There are also gene expression patterns that are characteristic of particular kinds of oncogene activities and then if you can identify the oncogene that is characteristically over expressed or poorly expressed in a particular tumor, you can then make drugs against it and Gleevecâ„¢ and Iressaâ„¢ are drugs of that kind.
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- ID: 15046
- Source: DNALC.DNAi
David Botstein talks about the goal of using microarray analysis to improve cancer diagnosis.
Mary-Claire King speaks about how much was yet to be understood about the genetic mechanisms of cancer when she began her hunt for genes associated with breast cancer.
David Botstein (sitting with Pat Brown) talks about how innovations in genomics might lead to personalized medicine.
David Botstein talks about how tumor typing using genome-wide analysis will help doctors determine the most appropriate treatments for their patients.
Stephen Fodor talks about how an individual's gene expression profile can help determine what therapies might work best.
Pat Brown talks about using microarrays to discover the differences between cancer cells and healthy cells.
In this section pharmacogenetics is discussed and how people can have very different responses to the same drug and treatment.
This section identifies that a cancer gene alters the normal functioning of a protein, and there are three major categories of cancer genes.
All cancers are genetic, in that cancers are caused by genetic mutations in genes that lead to malignancy.
Professor Bert Vogelstein, explains that cancer is in essence a genetic disease. It is caused by mutations of genes and there are three types of genes, that contribute to cancer.