Using DNA microarrays to study cancer, Patrick Brown
Interviewee: Pat Brown. Pat Brown talks about using microarrays to discover the differences between cancer cells and healthy cells. (DNAi Location: Applications > Genes and medicine > genetic profiling > Patrick Brown > Using microarrays to study cancer)
Well we knew that differences in the gene expression program were largely responsible for the differences in the appearance and the behavior of the normal cells in our body, say a brain cell compared to a liver cell. And so it seemed natural that by looking systematically at the gene expression program in cancer cells, we would be able to get a better understanding of why those cells are different from their normal counterpart and why a breast cancer in one woman looks and behaves differently from a breast cancer in another woman.
microarray gene expression,dna microarrays,dna gene,cancer cells,liver cell,breast cancer,brain cell,genetic profiling,location applications,pat brown,dnai,interviewee,counterpart,genes,appearance,medicine
- ID: 15040
- Source: DNALC.DNAi
- Download: Theora Video MPEG 4 Video
Related Content
15039. What's on a microarray, Patrick Brown
Pat Brown talks about how the 30,000 spots on the microarray represent genes.
15036. Why we developed the microarray, Patrick Brown
Pat Brown talks about developing microarray technology for genome-wide analysis.
15038. Making a DNA microarray, Patrick Brown
Pat Brown discusses the early technology behind the microarray.
15992. DNA microarrays
DNA microarrays provide the means to analyze patterns of gene expression at different timepoints in a living cell.
15037. The genome is the script, Patrick Brown
Pat Brown draws an analogy between the genome and a script that tells a cell how to behave.
15542. DNA microarray output
DNA microarrays provide the means to analyze patterns of gene expression at different timepoints in a living cell.
15053. Gene profile and response to treatment, Stephen Fodor
Stephen Fodor talks about how an individual's gene expression profile can help determine what therapies might work best.
15048. Better diagnosis, David Botstein
David Botstein talks about the goal of using microarray analysis to improve cancer diagnosis.
15121. Little known in the 1970s about the causes of cancer, Mary-Claire King
Mary-Claire King speaks about how much was yet to be understood about the genetic mechanisms of cancer when she began her hunt for genes associated with breast cancer.
15920. DNA arrays
In the 1990s, DNA arrays provided the means to analyze patterns of gene expression at different timepoints in a living cell.