What's on a microarray, Patrick Brown
Interviewee: Pat Brown. Pat Brown talks about how the 30,000 spots on the microarray represent genes. (DNAi Location: Applications > Genes and medicine > genetic profiling > Patrick Brown > What's on a microarray)
So this is how we represent the human genome in a microarray. It, as you can see there are about thirty thousand spots representing roughly the thirty thousand genes that we currently recognize in the human genome, and this gives us a way to, whenever we look at a cell or a tissue sample, to recognize which genes are being used and how they're being used in a particular cell or a tissue or a process.
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Pat Brown talks about developing microarray technology for genome-wide analysis.
Pat Brown talks about using microarrays to discover the differences between cancer cells and healthy cells.
Pat Brown discusses the early technology behind the microarray.
Pat Brown draws an analogy between the genome and a script that tells a cell how to behave.
David Botstein (sitting with Pat Brown) talks about how innovations in genomics might lead to personalized medicine.
DNA microarrays provide the means to analyze patterns of gene expression at different timepoints in a living cell.
Stephen Fodor talks about how an individual's gene expression profile can help determine what therapies might work best.
Stephen Fodor talks about bringing the knowledge gathered by the Human Genome Project to the individual researcher.
David Botstein discusses how identifying the molecular mechanisms of cancer will lead to the development of improved therapies.
David Botstein talks about the goal of using microarray analysis to improve cancer diagnosis.