Why we developed the microarray, Patrick Brown
Interviewee: Patrick (Pat) Brown. Pat Brown talks about developing microarray technology for genome-wide analysis. (DNAi Location: Applications > Genes and medicine > genetic profiling > Patrick Brown > Why we developed the microarray)
When we started developing the microarray technology it was to enable a new method for relating sequence differences in genes to complex traits in people, that was the idea. When we began doing experiments we realized that the microarrays could be used to characterize essentially any property of a gene on a genome-wide basis, to look at the whole genome, all the genes in the genome and not only look at things like heritable differences in sequences but look at dynamic behavior of the genes.
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Pat Brown talks about using microarrays to discover the differences between cancer cells and healthy cells.
Pat Brown talks about how the 30,000 spots on the microarray represent genes.
Pat Brown discusses the early technology behind the microarray.
Pat Brown draws an analogy between the genome and a script that tells a cell how to behave.
DNA microarrays provide the means to analyze patterns of gene expression at different timepoints in a living cell.
In the 1990s, DNA arrays provided the means to analyze patterns of gene expression at different timepoints in a living cell.
Stephen Fodor talks about bringing the knowledge gathered by the Human Genome Project to the individual researcher.
David Botstein (sitting with Pat Brown) talks about how innovations in genomics might lead to personalized medicine.
Patrick Brown works with microarrays at Stanford University.