GeneChip™ technology, Stephen Fodor
Interviewee: Stephen Fodor. Stephen Fodor talks about bringing the knowledge gathered by the Human Genome Project to the individual researcher. (DNAi Location: Applications > Genes and medicine > Genetic profiling > Stephen Fodor > GeneChip™ technology)
Well, in the early '80s the decision had been made to attempt to sequence the human genome. And in the later part of that decade we were thinking about how to create a technology that could actually bring the human genome to the individual researcher. And the DNA chip technology, or the GeneChip™ technology is the technology that can actually perform that. It's a marriage of both life sciences chemistry with Silicon Valley manufacturing processes that allow you to take the basic building blocks of DNA, the A, the C, the G and the T, and build different combinations of those building blocks in order to make different strands of DNA.
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Stephen Fodor continues his discussion of the experiments that laid the groundwork for GeneChip technology.
Stephen Fodor discusses the experiments that laid the groundwork for GeneChip technology.
Stephen Fodor talks about manufacturing the gene chip.
Stephen Fodor talks about the photolithographic technique used to synthesize pieces of DNA on the surface of GeneChipsÂ®.
Stephen Fodor talks about how an individual's gene expression profile can help determine what therapies might work best.
Stephen Fodor talks about the need to look broadly across the genome to find the relationship between genes and health in different people.
Stephen Fodor talks about limit to the gene chip.
Pat Brown discusses the early technology behind the microarray.
Steve Fodor changed the way genomes can be screened with GeneChipsÂ®.
Stephen Fodor talks about understanding genes and health.