Understanding genes and health, Stephen Fodor
Interviewee: Stephen Fodor. Stephen Fodor talks about understanding genes and health.
We can ask the question which genes are turned on and off, by looking at expression levels, that is the MRNA that is produced directly off the DNA can be analysed on these chips. Now there are a lot of studies that will be done looking at the expression of the genome, all the way from looking at developmental issues, what makes one cell different than another, looking at disease issues, why is this cell sick, response issues if I treat it with a drug, what effect does it have, and of course simple therapeutic monitoring or signature issues that can be predictive for what we might, therapeutic outcomes for example. These are all areas that we need to study in different individuals, in different tissue types, in different organisms, in order to understand what is the basic circuitry of life and what does it mean with respect to health.
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Stephen Fodor personalized medicine.
Stephen Fodor talks about how an individual's gene expression profile can help determine what therapies might work best.
Stephen Fodor talks about bringing the knowledge gathered by the Human Genome Project to the individual researcher.
Igor Dawid and Thomas Sargent explain how they developed subtractive mRNA hybrization to find genes expressed by different cell types. Pat Brown and Steve Fodor show how genomes can be screened with DNA arrays and GeneChips™
Stephen Fodor discusses the experiments that laid the groundwork for GeneChip technology.
Stephen Fodor talks about the need to look broadly across the genome to find the relationship between genes and health in different people.
Stephen Fodor talks about limit to the gene chip.
Stephen Fodor talks about manufacturing the gene chip.
Steve Fodor changed the way genomes can be screened with GeneChipsÂ®.
Stephen Fodor continues his discussion of the experiments that laid the groundwork for GeneChip technology.