How GeneChipâ„¢ was developed (Part I), Stephen Fodor
Interviewee: Stephen Fodor. Stephen Fodor discusses the experiments that laid the groundwork for GeneChipâ„¢ technology. (DNAi Location: Applications > Genes and medicine > genetic profiling > Stephen Fodor > How the chip was developed-Part I)
Developing out the GeneChipâ„¢ technology was pretty much like everything else that's done in this world, it was through experimentation. And we had some wonderful ideas about how to do this, but the first real experiments were almost high school lab type experiments. We took the basic building blocks of nature, the A, C, G and T, prepared them in a way so that we could do chemical synthesis with them, but then the question was, how do you lay this out on a surface. And the first experiments in fact were to do very simple experiments, where for example we printed up checkerboards on a printer and then took a picture of that checkerboard, had the film developed and then used that film as a guide to, to describe which regions of the array would be illuminated and which ones would be dark.
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Stephen Fodor continues his discussion of the experiments that laid the groundwork for GeneChip technology.
Stephen Fodor talks about bringing the knowledge gathered by the Human Genome Project to the individual researcher.
Stephen Fodor talks about how an individual's gene expression profile can help determine what therapies might work best.
Stephen Fodor talks about the need to look broadly across the genome to find the relationship between genes and health in different people.
Stephen Fodor talks about the photolithographic technique used to synthesize pieces of DNA on the surface of GeneChipsÂ®.
Stephen Fodor personalized medicine.
Pat Brown discusses the early technology behind the microarray.
In the early 1990s, Stephen Fodor and his team developed a technique to produce miniature arrays of biological molecules
Pat Brown talks about developing microarray technology for genome-wide analysis.
Igor Dawid and Thomas Sargent explain how they developed subtractive mRNA hybrization to find genes expressed by different cell types. Pat Brown and Steve Fodor show how genomes can be screened with DNA arrays and GeneChips™