How GeneChipâ„¢ was developed (Part I), Stephen Fodor

Interviewee: Stephen Fodor. Stephen Fodor discusses the experiments that laid the groundwork for GeneChipâ„¢ technology. (DNAi Location: Applications > Genes and medicine > genetic profiling > Stephen Fodor > How the chip was developed-Part I)

Developing out the GeneChipâ„¢ technology was pretty much like everything else that's done in this world, it was through experimentation. And we had some wonderful ideas about how to do this, but the first real experiments were almost high school lab type experiments. We took the basic building blocks of nature, the A, C, G and T, prepared them in a way so that we could do chemical synthesis with them, but then the question was, how do you lay this out on a surface. And the first experiments in fact were to do very simple experiments, where for example we printed up checkerboards on a printer and then took a picture of that checkerboard, had the film developed and then used that film as a guide to, to describe which regions of the array would be illuminated and which ones would be dark.

stephen fodor,basic building blocks,genechip technology,chemical synthesis,genetic profiling,dnai,location applications,gene expression,interviewee,groundwork,genome,genes,dna,array,medicine

Related Content

15051. How GeneChip™ was developed (Part II), Stephen Fodor

Stephen Fodor continues his discussion of the experiments that laid the groundwork for GeneChip™ technology.

  • ID: 15051
  • Source: DNAi

15049. GeneChip™ technology, Stephen Fodor

Stephen Fodor talks about bringing the knowledge gathered by the Human Genome Project to the individual researcher.

  • ID: 15049
  • Source: DNAi

15053. Gene profile and response to treatment, Stephen Fodor

Stephen Fodor talks about how an individual's gene expression profile can help determine what therapies might work best.

  • ID: 15053
  • Source: DNAi

15052. Effects of DNA variation on health, Stephen Fodor

Stephen Fodor talks about the need to look broadly across the genome to find the relationship between genes and health in different people.

  • ID: 15052
  • Source: DNAi

15083. Making DNA chips, Stephen Fodor

Stephen Fodor talks about the photolithographic technique used to synthesize pieces of DNA on the surface of GeneChips®.

  • ID: 15083
  • Source: DNAi

16115. Personalized medicine, Stephen Fodor

Stephen Fodor personalized medicine.

  • ID: 16115
  • Source: DNAi

15038. Making a DNA microarray, Patrick Brown

Pat Brown discusses the early technology behind the microarray.

  • ID: 15038
  • Source: DNAi

15919. GeneChip™

In the early 1990s, Stephen Fodor and his team developed a technique to produce miniature arrays of biological molecules

  • ID: 15919
  • Source: DNAi

15036. Why we developed the microarray, Patrick Brown

Pat Brown talks about developing microarray technology for genome-wide analysis.

  • ID: 15036
  • Source: DNAi

16736. Animation 36: Different genes are active in different kinds of cells.

Igor Dawid and Thomas Sargent explain how they developed subtractive mRNA hybrization to find genes expressed by different cell types. Pat Brown and Steve Fodor show how genomes can be screened with DNA arrays and GeneChips™

  • ID: 16736
  • Source: DNALC.DNAFTB