How GeneChipâ„¢ was developed (Part II), Stephen Fodor
Interviewee: Stephen Fodor. Stephen Fodor continues his discussion of the experiments that laid the groundwork for GeneChipâ„¢ technology. (DNAi Location: Applications > Genes and medicine > Genetic profiling > Stephen Fodor > How the chip was developed-Part II)
Another very important area that needed to be worked out was the combinatorics. Of course if you're going to be making an array with five hundred thousand or with a million different features on it, with a different strand of DNA in each spot, you can't afford from a manufacturing way to use five hundred thousand or a million steps to do this. And so we came up with some very elegant combinatorial chemistry techniques that allows us to actually make many, many compounds in very, very few chemical steps. And so it was really this union of photolithography, synthetic chemistry, as well as the idea of how life uses combinatorial building blocks to build diversity, that we used in order to build the so-called DNA chip.
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Stephen Fodor talks about bringing the knowledge gathered by the Human Genome Project to the individual researcher.
Stephen Fodor discusses the experiments that laid the groundwork for GeneChip technology.
Stephen Fodor talks about the photolithographic technique used to synthesize pieces of DNA on the surface of GeneChipsÂ®.
Stephen Fodor talks about how an individual's gene expression profile can help determine what therapies might work best.
In the early 1990s, Stephen Fodor and his team developed a technique to produce miniature arrays of biological molecules
Steve Fodor changed the way genomes can be screened with GeneChipsÂ®.
Igor Dawid and Thomas Sargent explain how they developed subtractive mRNA hybrization to find genes expressed by different cell types. Pat Brown and Steve Fodor show how genomes can be screened with DNA arrays and GeneChips™
Stephen Fodor talks about the need to look broadly across the genome to find the relationship between genes and health in different people.
Stephen Fodor is Chairman and CEO of Affymetrix, Inc
Stephen Fodor talks about limit to the gene chip.