Limit to the gene chip, Stephen Fodor.
Interviewee: Stephen Fodor. Stephen Fodor talks about limit to the gene chip.
If you think about putting the entire genome on a chip, the entire genome is roughly three billion base pairs, or the non-repetitive part of the genome is maybe two billion base pairs. So you might say, well once I put two billion bases on there, or two billion different strands of DNA to detect all of those bases, isn't that sort of the limit. Well it is, if what you're trying to do is simply detect those particular sequences. Of course there's another phenomenon in biology which is called polymorphism, and that is that individuals carry changes to their DNA. So if you want to start building variations of sequence on the chip, there's almost an endless number of questions that one might ask in terms of the different variants of DNA that you may want to detect.
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Stephen Fodor talks about bringing the knowledge gathered by the Human Genome Project to the individual researcher.
Stephen Fodor talks about manufacturing the gene chip.
Stephen Fodor talks about the need to look broadly across the genome to find the relationship between genes and health in different people.
In the early 1990s, Stephen Fodor and his team developed a technique to produce miniature arrays of biological molecules
Stephen Fodor talks about the photolithographic technique used to synthesize pieces of DNA on the surface of GeneChipsÂ®.
Stephen Fodor continues his discussion of the experiments that laid the groundwork for GeneChip technology.
Stephen Fodor personalized medicine.
Stephen Fodor talks about understanding genes and health.
Stephen Fodor is Chairman and CEO of Affymetrix, Inc
Stephen Fodor discusses the experiments that laid the groundwork for GeneChip technology.