Microarray Studies - Danger of False Positives
Doctor Anil Malhotra discusses that because whole genome microarray studies examine so much genetic data, the daners of false-positive results are very real.
Yes. One of the limitations when you examine so many different numbers of markers at any individual time point is the potential for false-positive results. Because of that, the level of statistical correction for multiple testings is quite stringent, and thus we hope to limit the number of false-positives by doing that. But the critical aspect of this probably will be replication of results in multiple studies. I think that will provide more confidence in results than simply a statistical p-value.
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Doctor Anil Malhotra discusses the problem of deciding what meets the criteria for statistical significance for microarray studies.
Doctor Anil Malhotra discusses the search for genes in both bipolar disorder and schizophrenia, both of which are in their infancy.
Doctor Anil Malhotra discusses new technologies that allow scientists to genotype large numbers of genetic polymorphisms.
Doctor Anil Malhotra discusses emerging research relating specific genes to positive (DISC1) and negative (e.g. dysbindin) symptoms of schizophrenia.
Doctor Anil Malhotra the positive and negative symptoms of schizophrenia - individuals with the disorder typically have a mix of both sets of symptoms.
Jonathan Sebat, a researcher at Cold Spring Harbor Laboratory, discusses how association studies are used to determine the causes of genetic disorders.
Doctor Anil Malhotra discusses endophenotype strategies for studying schizophrenia, which can examine neurocognitive function or brain-imaging.
Doctor Anil Malhotra compares (older) linkage and (more modern) association techniques for identifying candidate genes for disorders.
Doctor Anil Malhotra discusses how transcription factors can turn genes on or off, possibly leading to increased or reduced risk of illness.
DNA microarrays provide the means to analyze patterns of gene expression at different timepoints in a living cell.