Microarray Studies - Assessing Statistical Significance
Doctor Anil Malhotra discusses the problem of deciding what meets the criteria for statistical significance for microarray studies.
I think it is fair to say that different research groups have different ideas and theories about how to achieve or what meets the criteria for statistical significance. Many groups apply a very simple correction called the Bonferroni correction, which is somewhat conservative and leads to a p-value which is being required on the order of 10-7 or 10-8 for a whole genome association study. Other groups have taken the approach of simply examining the best 20, 50, or 100 results in any individual data set and then comparing those to another data set perhaps across the top 20, 50, or 100 and looking for commonalities between these kinds of studies.
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Doctor Anil Malhotra discusses that because whole genome microarray studies examine so much genetic data, the daners of false-positive results are very real.
Doctor Anil Malhotra discusses new technologies that allow scientists to genotype large numbers of genetic polymorphisms.
Doctor Anil Malhotra discusses the search for genes in both bipolar disorder and schizophrenia, both of which are in their infancy.
Doctor Anil Malhotra discusses endophenotype strategies for studying schizophrenia, which can examine neurocognitive function or brain-imaging.
Doctor Anil Malhotra discusses how transcription factors can turn genes on or off, possibly leading to increased or reduced risk of illness.
Doctor Anil Malhotra discusses emerging research relating specific genes to positive (DISC1) and negative (e.g. dysbindin) symptoms of schizophrenia.
Doctor Anil Malhotra the positive and negative symptoms of schizophrenia - individuals with the disorder typically have a mix of both sets of symptoms.
Doctor Anil Malhotra compares (older) linkage and (more modern) association techniques for identifying candidate genes for disorders.
Doctor Anil Malhotra discusses antipsychotic treatments for schizophrenia, where medication regularly throughout lifetime is often recommended.
Doctor Anil Malhotra compares the effectiveness of of second generation antipsychotic medications, such as Clozapine, with earlier medications.