Transcription Factors Can Turn Genes On and Off
Doctor Anil Malhotra discusses how transcription factors can turn genes on or off, possibly leading to increased or reduced risk of illness.
It is possible that genes can be turned on and turned off by stress or again exposure to environmental events. Perhaps these events could turn on transcription factors in the genes of interest, thus leading to increased gene expression of these genes. Similarly, genes can be blocked or the transcription of genes can be blocked by certain events and that is also possible.
transcription factors, schizophrenia, genes, stress, gene expression, Anil, Malhotra
Doctor Anil Malhotra discusses the search for genes in both bipolar disorder and schizophrenia, both of which are in their infancy.
Doctor Anil Malhotra discusses endophenotype strategies for studying schizophrenia, which can examine neurocognitive function or brain-imaging.
Doctor Anil Malhotra discusses emerging research relating specific genes to positive (DISC1) and negative (e.g. dysbindin) symptoms of schizophrenia.
Doctor Anil Malhotra compares (older) linkage and (more modern) association techniques for identifying candidate genes for disorders.
Doctor Anil Malhotra discusses new technologies that allow scientists to genotype large numbers of genetic polymorphisms.
Doctor Anil Malhotra the positive and negative symptoms of schizophrenia - individuals with the disorder typically have a mix of both sets of symptoms.
Professor Pat Levitt explains that progenitor cells express transcription factors that determine whether the cell becomes a neuron.
Promoters are DNA sequences located in the 5' region adjacent to the transcriptional start site.
Doctor Anil Malhotra discusses antipsychotic treatments for schizophrenia, where medication regularly throughout lifetime is often recommended.
Doctor Anil Malhotra compares the effectiveness of of second generation antipsychotic medications, such as Clozapine, with earlier medications.