Schizophrenia - Do Genes Correspond to Symptoms?

Doctor Anil Malhotra discusses emerging research relating specific genes to positive (DISC1) and negative (e.g. dysbindin) symptoms of schizophrenia.

An area of emerging interest is to look not just the diagnosis of schizophrenia as a phenotype but to look at symptom profiles of patients as a phenotype in these genetic studies. Our group at Zucker Hillside has focused a fair amount on looking at the gene dysbindin and we have noted that dysbindin seems to be associated with lifetime-severity of negative symptoms in our data set. This has been observed by other groups also. Other genes such as DISC1 we observe to be associated with positive symptoms. There is a large body of work now going on and we are trying to dissect the symptomatic heterogeneity of schizophrenia and looking at specific candidate genes and their relationships to symptomatology.

symptom profiles, diagnosis of schizophrenia, candidate genes, genetic studies, phenotype, heterogeneity, schizophrenia, severity, Anil, Malhotra

Related Content

2301. Endophenotype Approach to Schizophrenia Research

Doctor Anil Malhotra discusses endophenotype strategies for studying schizophrenia, which can examine neurocognitive function or brain-imaging.

  • ID: 2301
  • Source: G2C

2318. Symptoms of Schizophrenia are Mixed

Doctor Anil Malhotra the positive and negative symptoms of schizophrenia - individuals with the disorder typically have a mix of both sets of symptoms.

  • ID: 2318
  • Source: G2C

2300. Studies of Genes in Bipolar Disorder and Schizophrenia

Doctor Anil Malhotra discusses the search for genes in both bipolar disorder and schizophrenia, both of which are in their infancy.

  • ID: 2300
  • Source: G2C

2313. Linkage versus Association Studies

Doctor Anil Malhotra compares (older) linkage and (more modern) association techniques for identifying candidate genes for disorders.

  • ID: 2313
  • Source: G2C

2299. Transcription Factors Can Turn Genes On and Off

Doctor Anil Malhotra discusses how transcription factors can turn genes on or off, possibly leading to increased or reduced risk of illness.

  • ID: 2299
  • Source: DNALC.G2C

868. Candidate Genes for Schizophrenia

An interactive chromosome map of the genes and loci associated with schizophrenia.

  • ID: 868
  • Source: G2C

1362. Schizophrenia (lesson)

Students will learn to determine symptoms of schizophrenia, examine the relationships among genes, neurotransmitters, and identify relevant brain structures.

  • ID: 1362
  • Source: G2C

2226. Schizophrenia

An overview of schizophrenia-related content on Genes to Cognition Online.

  • ID: 2226
  • Source: G2C

1291. Schizophrenia - A Review

A review of the causes, symptoms, and treatments of schizophrenia.

  • ID: 1291
  • Source: G2C

2314. Treating Schizophrenia with Antipsychotic Medication

Doctor Anil Malhotra discusses antipsychotic treatments for schizophrenia, where medication regularly throughout lifetime is often recommended.

  • ID: 2314
  • Source: G2C