Schizophrenia - Do Genes Correspond to Symptoms?
Doctor Anil Malhotra discusses emerging research relating specific genes to positive (DISC1) and negative (e.g. dysbindin) symptoms of schizophrenia.
An area of emerging interest is to look not just the diagnosis of schizophrenia as a phenotype but to look at symptom profiles of patients as a phenotype in these genetic studies. Our group at Zucker Hillside has focused a fair amount on looking at the gene dysbindin and we have noted that dysbindin seems to be associated with lifetime-severity of negative symptoms in our data set. This has been observed by other groups also. Other genes such as DISC1 we observe to be associated with positive symptoms. There is a large body of work now going on and we are trying to dissect the symptomatic heterogeneity of schizophrenia and looking at specific candidate genes and their relationships to symptomatology.
symptom profiles, diagnosis of schizophrenia, candidate genes, genetic studies, phenotype, heterogeneity, schizophrenia, severity, Anil, Malhotra
Doctor Anil Malhotra discusses endophenotype strategies for studying schizophrenia, which can examine neurocognitive function or brain-imaging.
Doctor Anil Malhotra the positive and negative symptoms of schizophrenia - individuals with the disorder typically have a mix of both sets of symptoms.
Doctor Anil Malhotra discusses the search for genes in both bipolar disorder and schizophrenia, both of which are in their infancy.
Doctor Anil Malhotra compares (older) linkage and (more modern) association techniques for identifying candidate genes for disorders.
Doctor Anil Malhotra discusses how transcription factors can turn genes on or off, possibly leading to increased or reduced risk of illness.
An interactive chromosome map of the genes and loci associated with schizophrenia.
Students will learn to determine symptoms of schizophrenia, examine the relationships among genes, neurotransmitters, and identify relevant brain structures.
An overview of schizophrenia-related content on Genes to Cognition Online.
A review of the causes, symptoms, and treatments of schizophrenia.
Doctor Anil Malhotra discusses antipsychotic treatments for schizophrenia, where medication regularly throughout lifetime is often recommended.