Endophenotype Approach to Schizophrenia Research
Doctor Anil Malhotra discusses endophenotype strategies for studying schizophrenia, which can examine neurocognitive function or brain-imaging.
An alternative strategy for finding genes is the so-called endophenotype approach where we look for parts of the illness perhaps that are closer to gene action. Most popularly this has been either neurocognitive function or brain-imaging parameters, where we can collect these neurocognitive measures and brain-imaging measures in healthy controls and in patients with schizophrenia and then do our genetic analyses, where we try to find genes that influence neurocognition and brain-imaging. Perhaps then those genes also influence risks for schizophrenia.
phenotype, endophenotype, schizophrenia genetics, brain, imaging, neurocognition, Anil, Malhotra
Doctor Anil Malhotra discusses emerging research relating specific genes to positive (DISC1) and negative (e.g. dysbindin) symptoms of schizophrenia.
Doctor Anil Malhotra discusses the search for genes in both bipolar disorder and schizophrenia, both of which are in their infancy.
Doctor Anil Malhotra discusses how transcription factors can turn genes on or off, possibly leading to increased or reduced risk of illness.
Professor Daniel Geschwind explains that studying endophenotypes is a useful way to understand the complexities of autism.
Doctor Anil Malhotra the positive and negative symptoms of schizophrenia - individuals with the disorder typically have a mix of both sets of symptoms.
Professor Daniel Geschwind relates difficulties in studying a complex disorder like autism, where no two autistic individuals present with precisely the same symptoms.
Doctor Anil Malhotra discusses antipsychotic treatments for schizophrenia, where medication regularly throughout lifetime is often recommended.
Doctor Anil Malhotra discusses new technologies that allow scientists to genotype large numbers of genetic polymorphisms.
Doctor Anil Malhotra discusses that because whole genome microarray studies examine so much genetic data, the daners of false-positive results are very real.
Doctor Anil Malhotra compares (older) linkage and (more modern) association techniques for identifying candidate genes for disorders.