Studies of Genes in Bipolar Disorder and Schizophrenia
Doctor Anil Malhotra discusses the search for genes in both bipolar disorder and schizophrenia, both of which are in their infancy.
The search for genes in bipolar disorder parallels the search for genes in schizophrenia â€“ first linkage studies, then association studies, and now whole genome association studies. The search in bipolar disorder may have been a little bit less successful than those in schizophrenia although people could argue that. The whole genome association results that we have seen so far are relatively equivocal both for schizophrenia and for bipolar disorder, so I think it is a little difficult to say that bipolar disorder genetics has had less success than say schizophrenia genetics. I think both are really in their infancy at this point in time.
schizophrenia genetics, linkage studies, bipolar disorder, genes, association, linkage, microarray, Anil, Malhotra
Doctor Anil Malhotra compares (older) linkage and (more modern) association techniques for identifying candidate genes for disorders.
Professor James Potash describes the difference between linkage and association studies, which are two ways of locating candidate genes. These are discussed in reference to bipolar disorder,
Doctor Anil Malhotra discusses emerging research relating specific genes to positive (DISC1) and negative (e.g. dysbindin) symptoms of schizophrenia.
Doctor Anil Malhotra discusses that because whole genome microarray studies examine so much genetic data, the daners of false-positive results are very real.
Doctor Anil Malhotra discusses endophenotype strategies for studying schizophrenia, which can examine neurocognitive function or brain-imaging.
Doctor Anil Malhotra discusses the problem of deciding what meets the criteria for statistical significance for microarray studies.
Doctor Anil Malhotra discusses new technologies that allow scientists to genotype large numbers of genetic polymorphisms.
An overview of bipolar disorder-related content on Genes to Cognition Online.
Professor Allen Moore describes the differences between linkage and association studies, which are low- and high-resolution techniques used to search for candidate genes.
Doctor Anil Malhotra discusses how transcription factors can turn genes on or off, possibly leading to increased or reduced risk of illness.