Linkage versus association studies
Professor Allen Moore describes the differences between linkage and association studies, which are low- and high-resolution techniques used to search for candidate genes.
Linkage is actually looking at physical segments of the genome that are associated with given traits. Association studies go from the other direction, saying, â€˜given different pieces of the genome, can we then look for different traits that are associated with those different segments of genome?â€™ So we know that individuals donâ€™t have the same genetic makeup. They have the same DNA, but the DNA has different sequences or is expressed differently, and thatâ€™s what causes differences among different individuals. So the question is that if we have a trait, particularly a disease trait, can we find and associate that with differences among individuals in the population? So a linkage study is just saying, â€˜can we say that there is an association between pieces of the DNA and a trait of interest?â€™ Association studies are saying, â€˜what are the differences we see?' in order to find differences in the traits, particularly disease traits, among different individuals.
linkage study, association study, candidate genes, dna, sequences, allen, moore
Professor Allen Moore outlines the differences between quantitative genetics and linkage studies. With quantitative genetics it is not necessary to begin with the physical DNA.
Professor Allen Moor explains that quantitative genetics is a technique for determining candidate genes for traits or disorders associated with multiple genes.
Prof. Allen Moore explains that bioinformatics can deal with a huge amount of genomic data, allowing researchers to explore complex relationships between many genes or genomes.
Professor Allen Moore explains that the DNA code is a long sequence made up of four bases (A,C,T, and G) and DNA sequencing is the processes of identifying the order in which they occur.
Doctor Anil Malhotra compares (older) linkage and (more modern) association techniques for identifying candidate genes for disorders.
Professor Daniel Weinberger discusses research that makes dysbindin a candidate gene for schizophrenia.
Professor James Potash describes the difference between linkage and association studies, which are two ways of locating candidate genes. These are discussed in reference to bipolar disorder,
Professor Allen Moore explains that expression analysis allows researchers to study what it is that the gene is making.
Professor Allen Moore explains that since the beginning of the human genome project sequencing technology has become considerably cheaper and we now have sequences for many different organisms.
Professor Daniel Weinberger discusses research that makes neuregulin a candidate gene for schizophrenia.