Quantitative genetics studies
Professor Allen Moor explains that quantitative genetics is a technique for determining candidate genes for traits or disorders associated with multiple genes.
Well quantitative genetics is a statistical approach so rather then looking at the physical makeup (the DNA that causes differences in traits) you use associations between parents and offspring or between siblings and relatives. So relatives are more similar then unrelated individuals and so by keeping track of relatedness we can see whether individuals who are more similar in terms of relatedness are also more similar in a behavior or a phenotype that is more difficult to study. So you use quantitative genetics for those traits that arenâ€™t really simple traits like classic traits that are single gene traits whether or not you have an attached ear lobe, which may be caused by a single gene as opposed to how tall you are which is caused by many, many different genes, and it would be difficult to study all of those genes at once. So instead of looking at the genes we actually look at the phenotype, the trait that we are interested in, and associate it using statistical techniques.
quantitative genetics, candidate genes, siblings, offspring, relatives, dna, allen moore
Professor Allen Moore outlines the differences between quantitative genetics and linkage studies. With quantitative genetics it is not necessary to begin with the physical DNA.
Professor Allen Moore describes the differences between linkage and association studies, which are low- and high-resolution techniques used to search for candidate genes.
Professor Allen Moore explains that the DNA code is a long sequence made up of four bases (A,C,T, and G) and DNA sequencing is the processes of identifying the order in which they occur.
Prof. Allen Moore explains that bioinformatics can deal with a huge amount of genomic data, allowing researchers to explore complex relationships between many genes or genomes.
Professor Allen Moore explains that expression analysis allows researchers to study what it is that the gene is making.
Professor Allen Moore explains that since the beginning of the human genome project sequencing technology has become considerably cheaper and we now have sequences for many different organisms.
Professor Allen Moore explains that because females have a limited number of offspring compared to males they are slightly more discriminating in their choice of mate.
Doctor Anil Malhotra compares (older) linkage and (more modern) association techniques for identifying candidate genes for disorders.
Locate a disease gene by screening for markers linked to the gene.
Professor Daniel Weinberger discusses research that makes dysbindin a candidate gene for schizophrenia.