What is DNA sequencing?
Professor Allen Moore explains that the DNA code is a long sequence made up of four bases (A,C,T, and G) and DNA sequencing is the processes of identifying the order in which they occur.
DNA sequencing came about because the DNA code is made up of four different bases: A, T, C, and G. And so the question is 'when you have a different gene, what are the sequence of those bases?', and so you go through and actually identify whether its an A, a T, a C, or a G and you do that for the entire genome and then you have a genome sequence. So you can actually know the genetic makeup of an entire organism just by knowing those four bases, the order they occur in, and where they occur on a chromosome.
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Professor Allen Moore explains that since the beginning of the human genome project sequencing technology has become considerably cheaper and we now have sequences for many different organisms.
Professor Allen Moore outlines the differences between quantitative genetics and linkage studies. With quantitative genetics it is not necessary to begin with the physical DNA.
Professor Allen Moore describes the differences between linkage and association studies, which are low- and high-resolution techniques used to search for candidate genes.
Prof. Allen Moore explains that bioinformatics can deal with a huge amount of genomic data, allowing researchers to explore complex relationships between many genes or genomes.
The DNA sequencing method developed by Fred Sanger forms the basis of automated "cycle" sequencing reactions today.
A single nucleotide polymorphism, or SNP, occurs when two individuals in the population differ by a single letter in the DNA sequence.
Professor Allen Moor explains that quantitative genetics is a technique for determining candidate genes for traits or disorders associated with multiple genes.
Craig Venter, the leader of the private genome effort at Celera Genomics, talks about the sources of the DNA used in their sequence.
The finished sequence of the human genome was published in April, 2003.
Craig Venter talks about working with repeats.