Single Nucleotide Polymorphisms
A single nucleotide polymorphism, or SNP, occurs when two individuals in the population differ by a single letter in the DNA sequence.
The genetics of cognitive disorders is complex because diseases like schizophrenia or autism are associated with multiple genes. The genomic code is a long sequence written in only four letters â€“ A,G,T, and C, which correspond to Adenine, Guanine, Thymine, and Cytosine. A single nucleotide polymorphism, or SNP, occurs when two individuals in the population differ by a single letter in the DNA sequence. For instance, one individual may have a â€˜Gâ€™ at this position, and another individual may have a â€˜C.â€™ Changes in the DNA sequence can lead to changes in a geneâ€™s biological function. For example, a change in the DNA sequence can lead to a change in the sequence of the protein that is produced, or it may cause a protein to terminate prematurely.
snp, snps, single nucleotide polymorphism, dna, sequence, polymorphism, nucleotide, schizophrenia, autism, genetics, diseases
- ID: 554
- Source: DNALC.G2C
Mark Skolnick talks about using RFLPs or SNPs to study patterns in families
An image of a family tree depicting the occurance of single nucleotide polymorphisms.
Scans of the entire human genome turn up genes involved in common diseases.
Evolutionary geneticist Michael Hammer speaks about the markers used to analyze DNA variation in the Y chromosome.
Special techniques are used for screening each individual’s genome for millions of different SNPs. This kind of comparison is referred to as a genome-wide association study.
Matt Ridley talks about Mitochondrial DNA.
Doctor Anil Malhotra discusses new technologies that allow scientists to genotype large numbers of genetic polymorphisms.
Jonathan Sebat, a researcher at Cold Spring Harbor Laboratory, discusses how association studies are used to determine the causes of genetic disorders.
Locate a disease gene by screening for markers linked to the gene.
Igor Dawid and Thomas Sargent explain how they developed subtractive mRNA hybrization to find genes expressed by different cell types. Pat Brown and Steve Fodor show how genomes can be screened with DNA arrays and GeneChips™