Professor Allen Moore explains that expression analysis allows researchers to study what it is that the gene is making.
Genetics works by, you have a gene, the gene then is expressed and makes a protein. The protein then comes together to make traits. So when we are looking at traits, depending on the trait we are looking at, it may be quite a bit removed from the gene itself. So what we really need to know is what the gene is making. The other problem is that genes make proteins, but the gene may be used in different ways so you put together proteins in different ways, maybe splice that is pieces of gene maybe expressed differently at different times. So expression studies are asking really what is happening at the level of the gene what is being made, what is the product. Itâ€™s very nice because you can ask questions like if I have two different subjects, and one is doing one thing and the other is not you could ask, 'what genes are being expressed that are different between those two?' So expression studies ask what RNAâ€™s being made and then from that RNA what protein is going to be made?
expression studies, expression analysis, rna, protein, allen, moore
Professor Allen Moore describes the differences between linkage and association studies, which are low- and high-resolution techniques used to search for candidate genes.
Professor James Eberwine describes the primary functions of RNA-binding proteins, which include regulating tRNAs, degrading RNAs, synthesizing RNAs, and regulating multigenic gene expression.
Professor James Eberwine describes three ways in which experiences can change the gene-expression: changing RNA translation, movement, and potentially production.
Professor Allen Moore outlines the differences between quantitative genetics and linkage studies. With quantitative genetics it is not necessary to begin with the physical DNA.
Professor Allen Moor explains that quantitative genetics is a technique for determining candidate genes for traits or disorders associated with multiple genes.
David Botstein talks about the goal of using microarray analysis to improve cancer diagnosis.
Professor Allen Moore explains that because females have a limited number of offspring compared to males they are slightly more discriminating in their choice of mate.
Doctor Josh Dubnau explains that some genes are preferentially active in one part of the brain or body, while other genes are particular active in another location.
Professor David Porteous explains that DISC1 is expressed prominently in the hippocampus. More specifically, it is expressed in the mitochondria of hippocampal cells.
Prof. Allen Moore explains that bioinformatics can deal with a huge amount of genomic data, allowing researchers to explore complex relationships between many genes or genomes.