TMS Treatment for Depression
Doctor Abraham Zangen discusses how transcranial magnetic stimulation (TMS) can stimulate different areas of the brain and treat depression.
We apply the stimulation in animal models in various brain sites that are associated with reward like the nucleus accumbens which is the ventral striatum, and the prefrontal cortex, the prelimbic and infralimbic cortex in the animal models. In the human studies we do only prefrontal cortex stimulation, but we are able to reach deep portions of this region with a special coil that we have designed to stimulate deeper portions of this area because we know that the deeper layers actually innervate heavily into other reward regions, and in our studies we found that stimulation of the deeper layers are much more effective in terms of ratings for depression of severely depressed patients. We find much better effects when we stimulate deeper.
transcranial, magnetic, stimulation,TMS, depression, nucleus accumbens, ventral striatum, prefrontal cortex, areas of the brain, animal models, depressed patients, abraham, zangen
Doctor Abraham Zangen discusses a treatment developed by his group that uses transcranial magnetic stimulation (TMS) to treat depression.
Doctor Abraham Zangen describes how transcranial magnetic stimulation (TMS) may affect levels of BDNF in the hippocampus, thereby treating depression.
Doctor Abraham Zangen discusses two techniques for treating depression, which involve electrically stimulating the brain - transcranial magnietic stimulation (TMS) and deep brain stimulation (DBS).
Doctor Abraham Zangen point out that dopamine and BDNF levels in the nucleus accumbens and hippocampus of depressed patients are different. Treatment with antidepressants or ECT can impact these differences.
Doctor Abraham Zangen discusses the key structures underlying the brain reward system, a complex neural network that includes the nucleus accumbens and hippocampus.
Professor Wayne Drevets discusses the amygdala, striatum, and prefrontal cortex as neural correlates of bipolar disorder. Mania and depression may link to the dopamine system.
Professor Wayne Drevets explains that depression most commonly arises after puberty. There are exceptions, where it arises in childhood or in relatively late adulthood.
Doctor Jon Lieberman discusses three neurotransmitters that have been associated with depression - dopamine, serotonin, and norepinephrine.
Professor Wayne Drevets discusses specific types of learning deficits associated with depression. These may be caused by biochemical impairments in long-term potentiation.
Professor Trevor Robbins discusses the function of a set of structures called the basal ganglia, which seem to be involved in response selection.