Depression and Transcranial Magnetic Stimulation
Doctor Abraham Zangen discusses a treatment developed by his group that uses transcranial magnetic stimulation (TMS) to treat depression.
So what we have developed is a method in which instead of stimulating the whole brain like with ECT where there are some side effects like memory loss, we only stimulate the relevant areas in the brain that are related to the disease â€“ the depression â€“ or the increments in the reward system by localized electrodes in animals and animal models. We study how repeated stimulations of only very focal regions of the reward system affect the behavior and change the neurochemistry associated with depression. In humans we translate it by doing transcranial magnetic stimulation using alternating magnetic fields, which actually produces electric fields like an inserted electrode that focuses on regions that are again associated with the impairment in depression and therefore without inducing all the side effects, the cognitive side effects of the ECT. We can induce the same therapeutic effects in terms of high percentages of remission even in patients that suffer from depression.
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Doctor Abraham Zangen discusses two techniques for treating depression, which involve electrically stimulating the brain - transcranial magnietic stimulation (TMS) and deep brain stimulation (DBS).
Doctor Abraham Zangen discusses how transcranial magnetic stimulation (TMS) can stimulate different areas of the brain and treat depression.
Doctor Abraham Zangen describes how transcranial magnetic stimulation (TMS) may affect levels of BDNF in the hippocampus, thereby treating depression.
Doctor Abraham Zangen point out that dopamine and BDNF levels in the nucleus accumbens and hippocampus of depressed patients are different. Treatment with antidepressants or ECT can impact these differences.
Doctor Abraham Zangen explains that electroconvulsive therapy can be an effective treatment for patients who do not respond to antidepressant medication.
Doctor Jon Lieberman describes the experience of receiving electroconvulsive therapy - a painless procedure lasting a few seconds.
Doctor Jon Lieberman describes his experiences with treating depression, where antidepressant medication was abandoned in favor of electroconvulsive therapy (ECT).
Doctor Jon Lieberman dispels some of the myths surrounding electroconvulsive therapy (ECT), which can be an effective treatment for depression.
Doctor Abraham Zangen discusses the key structures underlying the brain reward system, a complex neural network that includes the nucleus accumbens and hippocampus.
Professor Helen Mayberg describes the dramatic changes observed in depressed patients treated with deep brain stimulation, discussing how this has impacted how we view the brain and treatment.