Altered BDNF and Dopamine Levels In Depression
Doctor Abraham Zangen point out that dopamine and BDNF levels in the nucleus accumbens and hippocampus of depressed patients are different. Treatment with antidepressants or ECT can impact these differences.
Yes. So I did not mention that but dopamine is also altered in the nucleus accumbens by brain stimulation and BDNF (brain-derived neurotrophic factor) is altered by repeated stimulation. However, in depressive patients, there are some observations of increased BDNF (brain-derived neurotrophic factor) levels in the nucleus accumbens unlike what we see in the hippocampus. [This is] in opposite direction of alteration in depressive patients, and antidepressant drugs or electroconvulsive therapy was shown to decrease BDNF levels in the accumbens, unlike what it does in the hippocampus. I think there is less data on that. There is a group in Texas actually studying and they are more focusing on the question of what happens to BDNF in the nucleus accumbens, and they show this type of inverse relationship between BDNF in the accumbens and the hippocampus. My lab is focusing right now especially on the changes in the hippocampus.
depression, bdnf, dopamine, nucleus, accumbens, hippocampus, depressive, antidepressant, brain derived neurotrophic factor, abraham, zangen
Doctor Abraham Zangen describes how transcranial magnetic stimulation (TMS) may affect levels of BDNF in the hippocampus, thereby treating depression.
Brain-derived neurotrophic factor (BDNF) is mainly expressed in the central nervous system. It has attracted much attention as a depression candidate gene.
Doctor Abraham Zangen discusses the key structures underlying the brain reward system, a complex neural network that includes the nucleus accumbens and hippocampus.
Individual variations in antidepressant treatment outcomes.
Doctor Abraham Zangen discusses how transcranial magnetic stimulation (TMS) can stimulate different areas of the brain and treat depression.
Doctor Jon Lieberman discusses three neurotransmitters that have been associated with depression - dopamine, serotonin, and norepinephrine.
Doctor Abraham Zangen discusses two techniques for treating depression, which involve electrically stimulating the brain - transcranial magnietic stimulation (TMS) and deep brain stimulation (DBS).
Doctor Abraham Zangen explains that clinical depression is extremely common, affecting one in ten people at some stage in their life.
Doctor Abraham Zangen explains that electroconvulsive therapy can be an effective treatment for patients who do not respond to antidepressant medication.
Professor Bruce McEwen introduces BDNF, a class of neurotrophic molecules released by excitatory neurotransmission and associated with key process and disorders.