BDNF - brain-derived neurotrophic factor
Professor Bruce McEwen introduces BDNF, a class of neurotrophic molecules released by excitatory neurotransmission and associated with key process and disorders.
BDNF [brain-derived neurotrophic factor] is, of course, one of a class of neurotrophic molecules produced by the brain actually, and also by blood cells and other cells of the body. In the brain, itâ€™s released from neurons when there is excitatory neurotransmission. It has short-term effects on the nervous system; it has also long-term effects â€“ our work and related work suggests that it is a permissive factor for plastic changes in the brain, for either changes in excitability, or in our case, changes in the growth or retraction of dendrites, the generation of synapses, or the retraction of synapses. Itâ€™s a facilitator, and it works in collaboration with other agents. For example, I mentioned IGF1 is the circulating hormone thatâ€™s taken up from the blood. When you exercise, it helps to stimulate neurogenesis. Well, BDNF also participates in enhancing neurogenesis. We donâ€™t know yet how they work together, if itâ€™s in a linear fashion or if itâ€™s in a converging fashion, because one of the things we know about all the hormones ([e.g.] steroid hormones which I happen to study), is that they work in concert with other agents, both in the brain and coming in outside. So their effects are largely conditional, depending on the activity of other systems.
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Professor Bruce McEwen discusses the remodeling of dendrites, which are affected by BDNF, TPA, cell-adhesion molecules, and a number of other factors.
Doctor Abraham Zangen point out that dopamine and BDNF levels in the nucleus accumbens and hippocampus of depressed patients are different. Treatment with antidepressants or ECT can impact these differences.
Brain-derived neurotrophic factor (BDNF) is mainly expressed in the central nervous system. It has attracted much attention as a depression candidate gene.
Doctor Abraham Zangen describes how transcranial magnetic stimulation (TMS) may affect levels of BDNF in the hippocampus, thereby treating depression.
Professor Bruce McEwen describes the blood-brain barrier, which prevents most proteins from accessing the brain. Selective proteins can cross the barrier, instigating processes such as neurogenesis.
Professor Bruce McEwen describes the endocrine system, which regulates hormones, the autonomic nervous and immune systems.
Professor Bruce McEwen describes some of the key players in the endocrine system - hypothalamus, pituitary gland, adrenal cortex, sex glands, and hormones.
Professor Bruce McEwen discusses differences between the sexes in coping with stress. These are mediated by hormonal, neural, and genetic factors.
Professor Bruce McEwen discusses how the amygdala is involved in processing fear and stress.
Individual variations in antidepressant treatment outcomes.