Biochemistry of Depression
Doctor Jon Lieberman discusses three neurotransmitters that have been associated with depression - dopamine, serotonin, and norepinephrine.
There are three major neurotransmitters associated with depression. The one we hear most about these days is serotonin, there is dopamine, and there is norepinephrine. I would like to say a little bit about dopamine because dopamine deficiency is found in the synapses of people who are drug-dependent or engage in compulsive behavior - compulsive gambling, compulsive spending, compulsive shopping. The major area of the brain that seems to be affected by substance abuse and compulsive behaviors is the nucleus accumbens.
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- ID: 1392
- Source: DNALC.G2C
Doctor Jon Lieberman discusses the propsed mechanism of Selective Serotonin Reuptake Inhibitors (SSRIs), a controversial treatment for depression.
Professor Daniel Weinberger explains that dopamine is the major focus of biochemical research into schizophrenia.
Professor Jeffrey Lieberman discusses the dopamine hypothesis, the predominant neurochemical theory of schizophrenia.
Serotonin is the biochemical most commonly associated with depression. Professor Wayne Drevets discusses other systems including norepinephrine, glutamate, and dopamine.
Professor Helen Mayberg describes treatments for depression: medication, therapy, or a combination of the two. About 40% of patients recover entirely, while about 10% do not respond.
Doctor Jon Lieberman describes some of the life-events that may have been a factor in his first major depressive episode at 52 years of age.
Professor Trevor Robbins explains that drug addiction involves chemical and neural processes with dopamine and the nucleus accumbens particularly important.
An overview of depression-related content on Genes to Cognition Online.
Doctor Ellen Leibenluft discusses some of the biochemicals that have been associated with bipolar disorder, including dopamine, serotonin, and glutamate.
Professor Philip Shaw discusses the relationship between serotonin and ADHD.