DNA sequencing, Leroy Hood
Interviewee: Leroy Hood. Leroy Hood talks about DNA sequencing.
Well the major reason DNA lends itself to it, much better than proteins, is the alphabet of DNA is just four different letters. And as Mike suggested, we were interested in using fluorescent methods for color-coding each of the four letters and being able to essentially read their order out in these long strings. And we knew that there were at least four different fluorescent dyes that had distinct spectra that could be detected. So this was a mechanism and a capacity that was well within the kind of technical means that we had in hand. And the idea that you could color-code the entire four-letter digital human genome and read it out was a very exciting one.
dna sequencing,leroy hood,human genome,fluorescent dyes,long strings,four letters,spectra,proteins,alphabet
- ID: 16119
- Source: DNALC.DNAi
- Download: MPEG 4 Video Theora Video
15097. Sequencing process, Leroy Hood
Leroy Hood explains the process of sequencing using an automated sequencing machines.
15096. Audacious idea of sequencing the human genome?, Leroy Hood
Leroy Hood talks about audacious idea of sequencing the human genome.
15656. Frederick Sanger, Michael Hunkapiller, and Leroy Hood
Frederick Sanger, Michael Hunkapiller, and Leroy Hood.
554. Single Nucleotide Polymorphisms
A single nucleotide polymorphism, or SNP, occurs when two individuals in the population differ by a single letter in the DNA sequence.
16341. Concept 15: DNA and proteins are key molecules of the cell nucleus.
DNA and protein are candidates for transmitting hereditary information.
15912. Sequencing DNA
Techniques to read the sequence of DNA, letter by letter, have been available since the 1970s. However, the massive task of sequencing the three billion basepairs of the human genome required machines that could read and interpret the data.
16358. Problem 15: DNA and proteins are key molecules of the cell nucleus.
Explore tetranucleotide combinations.
15527. DNA microarray
15365. Whole genome shotgun, Craig Venter
Craig Venter, the leader of the private genome effort, talks about the "whole genome shotgun" technique that was used by Celera Genomics to sequence the human genome.
2014. What is DNA sequencing?
Professor Allen Moore explains that the DNA code is a long sequence made up of four bases (A,C,T, and G) and DNA sequencing is the processes of identifying the order in which they occur.