Professor Jonathan Finch describes one technique for identifying genes in rodents.
The critical first step to mapping the genome involved finding genetic markers. These markers are unique sequences that provide orientation points in the genome landscape.
Barbara Weber shows how information from her study on genetic markers associated with inherited breast cancer indicated which family members were at increased risk and which were not.
By 1990, King had found a "landmark" that helped her fix the gene's position on a chromosome. This DNA marker was on chromosome 17, and was linked to breast cancer in a subset of the families she studied. She teamed up with Francis Collins in a race to f
Mary-Claire King talks about the tedious process of hunting for genes in the days before genetic maps (based on thousands of markers) were readily available.
Locate a disease gene by screening for markers linked to the gene.
Denise talks about the emotional moment when she found out she had been spared the "family curse."
Evolutionary geneticist Michael Hammer speaks about the markers used to analyze DNA variation in the Y chromosome.
James Watson describes sequencing the human genome using markers and BACs, and Craig Venter explains using cDNA libraries, ESTs, and shotgun sequencing.