Gene markers on chromosomes
By 1990, King had found a "landmark" that helped her fix the gene's position on a chromosome. This DNA marker was on chromosome 17, and was linked to breast cancer in a subset of the families she studied. She teamed up with Francis Collins in a race to find and clone the gene she named BRCA1.
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- ID: 15704
- Source: DNALC.DNAi
Mary-Claire King talks about her first steps toward finding the gene responsible for certain kinds of inherited breast cancer.
Geneticist Kenneth Kidd explains his study of human DNA variation in nuclear chromosomes.
Barbara Weber shows how information from her study on genetic markers associated with inherited breast cancer indicated which family members were at increased risk and which were not.
Watch the animation to learn more about why genetic markers offer important clues in the hunt for genes.
Evolutionary geneticist Michael Hammer speaks about the markers used to analyze DNA variation in the Y chromosome.
Mark Skolnick talks about the hunt for BRCA1.
Professor Jonathan Finch describes one technique for identifying genes in rodents.
Mary-Claire King talks about the search for a bit of DNA that would shed light on why some members of a family developed cancer while others did not.
Denise talks about learning about DNA, and deciding if she wanted to know if she was at increased risk for breast cancer.
Mary-Claire King talks about the tedious process of hunting for genes in the days before genetic maps (based on thousands of markers) were readily available.